September

September 18, 2018

Consuming a Probiotic once a day may insulate your heart against cardiac dysfunction: Probiotic Lactobacillus Plantarum-based adjunct therapy for cardiac hypertrophy and fibrosis: Probiotic Lactobacillus Plantarum decreases Mir-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 18/September/2018, 7.14 am

Introduction: What they say:   A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]
September 18, 2018

A new mechanistic insight into a known heart failure medicine in Pain therapy: Dobutamine (brand name: dobutrex, inotrex), used in the treatment of congestive heart failure and cardiogenic shock,  increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 18/September/2018, 6.24 am

Introduction: What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for […]
September 16, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Mibolerone (Trade name: Cheque drops and Matenon), an anabolic-androgenic steroid, increases the expression of tumor suppressors genes, such as HNF4α, CADM2, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 17/September/2018, 12.04 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
September 16, 2018

Combinatorial therapy for Metastatic ovarian cancers: A therapeutic mix encompassing Despiramine, Andrographlide, Radicicol, Atorvastatin, Salionomycin, Temozolomide, (DARAST) inhibits the expression of FABP4, increases the expression of a number of tumor suppressor genes, and stifles the metastatic potential and the progression of ovarian cancers, via up-regulation of its target gene, 16/September/2018, 11.18 pm

Introduction: What they say: A study from the Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, […]