Consuming good bacteria (Probiotic) may eliminate bad microbes: Probiotic Lactobacillus Rhamnosus-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Probiotic Lactobacillus Rhamnosus increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via upregulation of its target gene, 23/September/2018, 1.46 pm

A cup of Probiotic a day keeps stroke-risk at bay: Probiotic lactobacillus brevis attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 23/September/2018, 1.22 pm
September 23, 2018
The tiny Probiotic L. Rhamnosus may extend the lifespan of mighty humans: Probiotic Lactobacillus rhamnosus inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, 24/September/2018, 10.27 am
September 24, 2018
Show all

Introduction: What they say

A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows that “Interferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses.”  This research paper was published, in the 10 August 2016 issue of the journal “Cell Host and microbe” [One of the best research journals in Infectious biology with an I.F of 12.552], by Prof. Marco Vignuzzi, Bryan C. Mounce and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that:  Consuming good bacteria (Probiotic) may eliminate bad microbes: Probiotic Lactobacillus Rhamnosus-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Probiotic Lactobacillus Rhamnosus increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via upregulation of its target gene


What is known?

Prof. Marco Vignuzzi’s research team has recently shown that induction of type I interferon results in: a) upregulation of SAT1; b) depletion of spermidine and spermine levels; and c) inhibition of Chikungunya and Zika viruses production. They have further validated this by showing that exogenous administration of Polyamines (spermidine and spermine) restores virus replication.


From research findings to Therapeutic opportunity:

This study suggests, for the first time,  a Probiotic(good bacteria)-based antiviral therapy for RNA viruses, such as Chikungunya virus (CHIKV) and Zika virus (ZIKV). Probiotic Lactobacillus Rhamnosus, by increasing the expression of its target gene, it may increase the expression of spermidine/spermine N1-acetyltransferase (SAT1) (Figure 1). Thereby, it may: (1) decrease polyamine spermidine and spermine levels; (2) stall CHIKV and ZIKV replication; (3) promote clearance of Zika and Chikungunya Viruses; and (4) strengthen antiviral immunity against RNA viruses. (Figure 2)

Figure 1 Mechanistic insights into how  Probiotic Lactobacillus Rhamnosus functions as an antiviral agent. Probiotic Lactobacillus rhamnosus inhibits the replication of Chikungunya and Zika viruses through induction of SAT

Figure 2. Probiotic Lactobacillus rhamnosus functions as an anti-CHIKV/ZIKV agent

 

 

 

 

 

 

 

 

 

Thus, pharmacological formulations encompassing Probiotic Lactobacillus Rhamnosus, either alone or in combination with other drugs”, may be used to treat infections caused by chikungunya (CHIKV) and Zika (ZIKV) viruses. Given that probiotic-based therapy is more economical compared with chemical-based anti-viral therapy, Probiotic-based antiviral therapy may find larger utility in patient care throughout the world. 


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Probiotic Lactobacillus Rhamnosus decrease the expression of spermidine/spermine N1-acetyltransferase (SAT1)?

Amount: $1, 500#

For payment and purchase details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L,  Consuming good bacteria (Probiotic) may eliminate bad microbes: Probiotic Lactobacillus Rhamnosus-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Probiotic Lactobacillus Rhamnosus increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via upregulation of its target gene, 23/September/2018, 1.45 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite, drop us a line at admin@genomediscovery.org

Comments are closed.