Is music your way to keep the cardiac diseases at bay?: Music-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  Music  increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down-regulation of its target gene, 22/October/2018, 11.47 pm

Repurposing the anti-hypertensive drug Diazoxide  into a diabetic retinopathy drug: A pharmaceutical mixture encompassing Diazoxide, Epicatechin and Matrine (DEM) inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down-regulation of its target gene, 22/October/2018, 11.34 pm
October 22, 2018
Taming microbial infections with anti-tapeworm drugs:  Niclosamide (trade name: Niclocide, Fenasal, Phenasal), an anti-tapeworm drug, inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the antiviral Proteins IFITM3, & Interferon-stimulated gene 22/October/2018, 11.59 pm
October 22, 2018
Show all

Introduction: What they say

A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was published, in the 6 April  2015 issue of the journal “Nature cell biology” (the number 1 journal in “Cell biology” research with an impact factor of 20.761)by Prof Tzahor E, D’Uva E, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:   Is music your way to keep the cardiac diseases at bay?: Music-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  Music  increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down-regulation of its target gene


From the significance of the study to Public health relevance: 

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) the rise in death rate, due to cardiovascular disease, has increased from  123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs and (iv) a side-effect-free Natural product-based drug.


From research findings to Therapeutic opportunity: 

This study suggests, for the first time, provides detailed mechanistic insights into how Music may protect against cardiovascular diseases. Music, by increasing the expression of its target gene, it may: (1) increase ERBB2/Her2 expression; (2) induce cardiomyocyte (CM) dedifferentiation and proliferation, and (3) cardiomyocyte (CM) redifferentiation and regenerationThus, music therapy may be used to treat cardiac dysfunction. 

Figure1. Mechanistic insights into how Music may promote cardiac dedifferentiation and regeneration. Music, by increasing the expression of its target gene, it may upregulate the expression of ERRB2/HER2 and promote cardiac dedifferentiation and regeneration

Figure 2. Music may promote cardiac regeneration through induction of Her2/Erbb2

 

 

 

 

 

 

 

 

 

Given the mechanistic basis of how Music may aid in cardiomyocyte survival and regeneration medical practitioners and cardiologists may consider encouraging their myocardial patients to undergo music therapy, as it may aid in cardiomyocyte regeneration following myocardial infarction

[easy_payment currency=”USD”]


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $ 500#

Undisclosed (mechanistic insights) information: How does music increase the expression of  ERBB2/Her2?

For purchase and payment details, you may reach us at admin@genomediscovery.org

# Research cooperation


References: 

Web: http://genomediscovery.org or newbioideas.com

Citation: Boominathan, L.,  Is music your way to keep the cardiac diseases at bay?: Music-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  Music  increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down-regulation of its target gene, 22/October/2018, 11.46 pm,  Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite, drop us a line at info@genomediscovery.org

Comments are closed.