Mechanistic insights into how anti-anxiety agent Lorazepam may deteriorate memory, learning, and cognition: Lorazepam (trade name: Ativan, Tavor, Temesta, and other), a medication used in the treatment of anxiety, seizures, sedation, agitation and others, decreases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, attenuates cognition, and aggravates age-associated decline in memory and learning, via up-regulation of its target genes, 22/October/2018, 11.08 pm

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Introduction: What they say

A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California 94305, USA; Center for Tissue Regeneration, Repair and Restoration, V.A. Palo Alto Healthcare System, Palo Alto, California 94304, USA shows that “Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.” This research paper was published, in the 19 April 2017 issue of the journal “Nature” [One of the best research journals in General sciences with an I.F of 43+], by Prof.Tony Wyss-Coray, Joseph M. Castellano and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic insights into how anti-anxiety agent Lorazepam may deteriorate memory, learning, and cognition: Lorazepam (trade name: Ativan, Tavor, Temesta, and other), a medication used in the treatment of anxiety, seizures, sedation, agitation and others, decreases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, attenuates cognition, and aggravates age-associated decline in memory and learning, via up-regulation of its target genes


What is known?

Prof.Tony Wyss-Coray’s research team has recently shown that:  (1) human cord plasma treatment promotes cognitive and learning function in aged mice; (2) blood-borne component Tissue inhibitor of metalloproteinases 2 (TIMP2) is enriched in human cord plasma, young mouse plasma, and young mouse hippocampi; (3) TIMP2 increases hippocampal-dependent cognition; and (4) treating brain slices with TIMP2 antibody inhibits long-term potentiation and prevents hippocampal function, suggesting that increasing the expression of TIMP2 in aged individuals may enhance learning and memory.


From Research findings to Therapeutic opportunity:

A number of studies suggest that anesthetic agent Lorazepam may compromise cognition,  memory, and learning. However, the mechanism of action is far from clear. This study provides mechanistic insights into how repeated and the prolonged use of anesthetic agent Lorazepam may compromise cognition,  memory, and learning. Lorazepam, by increasing the expression of its target genes, may decrease the levels of TIMP2 and BDNF. Thereby, it may: (1) attenuate cognition and learning; (2) diminish spatial memory; and (3)  deteriorate hippocampal function (fig.1).

Figure1. Mechanistic insights into how the anesthetic agent Lorazepam may diminish learning, memory, and cognition. Lorazepam, by decreasing the expression of TIMP2, it decreases learning and memory in aged individuals.

Figure 2. John B. (Iain) Glen, who won the 2018 Lasker Clinical Medical Research Award (America’s Nobel), discovered the anesthetic agent Propofol. Lorazepam, by increasing the expression of its target genes, it may attenuate TIMB2 and BDNF expression. And thereby, it may attenuate learning, memory, and cognition


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How Lorazepam decreases the levels of TIMP2 and BDNF and attenuates memory and learning

Amount: $500#

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L.,  Mechanistic insights into how anti-anxiety agent Lorazepam may deteriorate memory, learning, and cognition: Lorazepam (trade name: Ativan, Tavor, Temesta, and other), a medication used in the treatment of anxiety, seizures, sedation, agitation and others, decreases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, attenuates cognition, and aggravates age-associated decline in memory and learning, via up-regulation of its target genes, 22/October/2018, 11.08 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

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