October

October 28, 2018

Repurposing the anti-pulmonary hypertensive drug into a longevity-promoting drug: Sitaxentan (trade name: Thelin), an anti-pulmonary hypertensive drug, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 28/October/2018, 1.55 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
October 28, 2018

A probiotic way to stay free of autoimmune diabetes: Probiotic Bifidobacterium bifidum increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up-regulation of its target gene, 28/September/2018, 1.00 pm

Introduction: What they say A study from the International Center for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, “L. Sacco” Department of Biomedical and Clinical […]
October 26, 2018

Repurposing the anti-inflammatory drug into a longevity-promoting drug: Sulindac, a nonsteroidal anti-inflammatory drug (NSAID), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target genes, 26/September/2018, 11.59 pm

What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal […]
October 26, 2018

Repurposing the anti-pulmonary hypertensive drug into a longevity-promoting drug: Ambrisentan(trade name: Letairis, Volibris, Pulmonext), an anti-pulmonary hypertensive drug, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 26/October/2018, 11.28 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]