Probiotic-based Antiviral therapy for Neuroinvasive West Nile virus: Probiotic Lactobacillus Rhamnosus increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via upregulation of its target gene, 12/October/2018, 2.17 am

A probiotic-based Cardiac rejuvenation therapy: Probiotic Lactobacillus Brevis suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy via upregulation of its target gene, 12/October/2018, 2.04 am
October 11, 2018
Analgesic pills as anti-infective agents:  Parecoxib (trade name: Dynastat), a selective Cox-2 inhibitor, inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the antiviral Proteins IFITM3, & Interferon-stimulated gene 12/October/2018, 2.27 am
October 11, 2018
Show all

Introduction: What they say

A study from the Department of Immunology, University of Washington, Seattle, WA 98109, USA; Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA 98109, USA shows that “RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.” This research paper was published, in the 30 March 2017 issue of the journal “Cell” [One of the best research journals in General biology with an I.F of 28.710], by Prof. Andrew OberstBrian P. Daniels and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Probiotic-based Antiviral therapy for Neuroinvasive West Nile virus: Probiotic Lactobcacillus Rhamnosus increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via upregulation of its target gene


What is known?

Prof. Andrew Oberst’s research team has recently shown that mice deficient in Receptor-interacting protein kinase-3 (RIPK3): a) are highly susceptible to neuroinvasive West Nile virus (WNV); b) poorly induce chemokine expression in neurons; and c) poorly recruit T lymphocytes and inflammatory myeloid cells in the central nervous system (CNS).


From research findings to Therapeutic opportunity:

This study suggests, for the first time, that Probiotic Lactobacillus Rhamnosus may aid in attenuating the replication of  RNA viruses such as neuroinvasive West Nile virus (WNV). Probiotic Lactobacillus Rhamnosus, by increasing the expression of its target gene, it may increase the expression of RIPK3 (Figure 1). Thereby, it may: (1) augment chemokine levels; (2) trigger neuroinflammation; (3) stall neuroinvasive West Nile virus replication; (4) promote clearance of neuroinvasive West Nile virus (WNV); and (5) strengthen antiviral immunity against RNA viruses.

Figure 1. Mechanistic insights into how Probiotic Lactobacillus Rhamnosus may function as an anti-viral agent. Probiotic Lactobacillus Rhamnosus inhibits neuroinvasive West Nile virus (WNV) pathogenesis via upregulation of its target gene RIPK3

Figure 2. Probiotic Lactobcacillus Rhamnosus inhibits neuroinvassive west nile virus production through induction of RIPK3.

Thus, pharmacological formulations encompassing Probiotic Lactobcacillus Rhamnosus or its analogs, either alone or in combination with any of the known antiviral compounds may be used to treat infections caused by neuroinvasive West Nile virus (Figures 1-2 ).


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Probiotic Lactobcacillus Rhamnosus increase the expression of Receptor-interacting protein kinase-3 (RIPK3)?

Amount: $300#

For payment and purchase details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., Probiotic-based Antiviral therapy for Neuroinvasive West Nile virus: Probiotic Lactobacillus Rhamnosus increases the expression of RIPK3, promotes chemokines production, inhibits neuroinflammation, and restricts neuroinvasive West Nile virus production and pathogenesis in neurons via upregulation of its target gene, 12/October/2018, 2.17 am, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite, drop us a line at admin@genomediscovery.org

Comments are closed.