Repurposing the anti-inflammatory drug into a longevity-promoting drug: Sulindac, a nonsteroidal anti-inflammatory drug (NSAID), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target genes, 26/September/2018, 11.59 pm
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October 26, 2018
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October 28, 2018What they say:
A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Repurposing the anti-inflammatory drug into a longevity-promoting drug: Sulindac, a nonsteroidal anti-inflammatory drug (NSAID), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target genes
Research findings to Therapeutic opportunity:
Figure 1. Mechanistic insight into how Sulindac may extend lifespan. Probiotic Bacillus licheniformis inhibits p70 S6 kInase expression and promotes longevity
Figure 2. Sulindac functions as a longevity-promoter
This study suggests, for the first time, that Sulindac, by increasing the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).
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Thus, pharmacological formulations encompassing “Sulindac, either alone or in combination with any of the known longevity-promoting compound(s),” may be used to extend the lifespan of an individual (fig. 1).
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic Information: How does Sulindac decrease the expression of p70 S6 Kinase and promotes mammalian lifespan?
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References:
Citation: Boominathan, L., Repurposing the anti-inflammatory drug into a longevity-promoting drug: Sulindac, a nonsteroidal anti-inflammatory drug (NSAID), inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target genes, 26/September/2018, 11.59 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org
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