Curry’s main ingredient/ coloring agent Curcumin may extend the lifespan of humans: Curcumin-based Lifespan extension therapy: Curcumin, found in turmeric,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 17/November/2018, 8.16 am

Probiotic-based therapy for pulmonary arterial hypertension (PAH): Bifidobacterium lactis LKM512-containing yogurt inhibits the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3, 17/November/2018, 12.11 am
November 16, 2018
Probiotic-based therapy for diabetic retinopathy: Probiotic Bifidobacterium lactis HY8101 inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down-regulation of its target gene, 17/November/2018, 8.35 am
November 17, 2018
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What they say:

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ),  by Prof. Dominic J. Withers, Dr. Selman C and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Curry’s main ingredient/ coloring agent Curcumin may extend the lifespan of humans: Curcumin-based Lifespan extension therapy: Curcumin, found in turmeric,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes


From research findings to Therapeutic Opportunity: 

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Figure 1. Curcumin may extend  mammalian lifespan via down-regulation of p70 S6 Kinase

Figure 2. The chemical structure of Curcumin.  It functions as a longevity-promoter by decreasing the expression of p70S6 Kinase and increasing the expression of other longevity-promoting genes

This study suggests, for the first time, a curcumin-based Lifespan-extension therapy. 

Curcumin, by regulating the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity(fig. 1).

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Thus, pharmacological formulations encompassing “curcumin or its analogs, either alone or in combination with any of the known longevity-promoting compound(s),” may be used to extend the lifespan of an individual (fig. 2).

 


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic Information: How curcumin decreases the expression of p70 S6 Kinase and promotes mammalian life span

# Research cooperation

Amount: $500#

For purchase and payment information, you may reach us at info@genomediscovery.org


References:

CitationBoominathan, L., Curry’s main ingredient/ coloring agent Curcumin may extend the lifespan of humans: Curcumin-based Lifespan extension therapy: Curcumin, found in turmeric,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 17/November/2018, 8.17 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite drop us a line at info@genomediscovery.org

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