Molecular therapy for enhanced learning, memory, and cognitive ability: AP-1 (Activator protein-1), comprising c-Jun and c-fos and others, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 28/November/2018, 1.25 pm

Molecular therapy for stroke: XBP-1 attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 28/November/2018, 12.33 pm
November 28, 2018
A probiotic way to keep the cardiac diseases at bay: Probiotic Lactobacillus reuteri-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  Probiotic Lactobacillus reuteri increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down-regulation of its target gene, 30/November/2018, 9.58 am
November 30, 2018
Show all
VSRP: No data available

Introduction: What they say:

A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California 94305, USA; Center for Tissue Regeneration, Repair and Restoration, V.A. Palo Alto Healthcare System, Palo Alto, California 94304, USA shows that “Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. This research paper was published, in the 19 April 2017 issue of the journal “Nature” [One of the best research journals in General sciences with an I.F of 43+], by Prof. Wyss-Coray, Castellano JM and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for enhanced learning, memory, and cognitive ability: AP-1 (Activator protein-1), comprising c-Jun and c-fos and others, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes


What is known?

Prof.Tony Wyss-Coray’s research team has recently shown that:  (1) human cord plasma treatment promotes cognitive and learning function in aged mice; (2) blood-borne component Tissue inhibitor of metalloproteinases 2 (TIMP2) is enriched in human cord plasma, young mouse plasma, and young mouse hippocampi; (3) TIMP2 increases hippocampal-dependent cognition; and (4) treating brain slices with TIMP2 antibody inhibits long-term potentiation and prevents hippocampal function, suggesting that increasing the expression of TIMP2 in aged individuals may enhance learning and memory.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, that AP-1 (Activator protien-1), comprising c-Jun and c-fos and others,  may play a role in enhancing learning, memory, and cognitive ability. AP-1, by increasing the expression of its target genes, may increase the levels of TIMP2. Thereby, it may: (1) increase the expression of genes that promote learning and memory; (2) cognition and learning; (3) improve spatial memory; and (4) promote hippocampal function (fig.1).

Figure 1. Activator protein-1 (AP-1) enhances learning, memory and cognition. AP-1, by increasing the expression of its target gene, it may increase the expression of BDNF amd TIMP2.

Figure 2. AP-1 functions as learning/memory/cognitive/longevity-enhancer through induction of TIMP2

 

[easy_payment currency=”USD”]

Thus, pharmacological formulations encompassing AP-1 or its activators or compounds that induce AP-1, either alone or in combination with other drugs, may be used to suppress the age-associated overall physiological decline of hippocampal function and improve cognition and memory (fig.2).


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does AP-1increase the levels of TIMP2?

Amount: $500#

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.c, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite, drop us a line at admin@genomediscovery.org

Citation: Molecular therapy for enhanced learning, memory, and cognitive ability: AP-1 (Activator protein-1), comprising c-Jun and c-fos and others, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 28/November/2018, 1.24 pm

 

Comments are closed.