Site is Being Upgraded

Probiotic-based therapy for cancer metastasis: Probiotic Lactobacillus Rhamnosus inhibits the expression of IL-6/8, decreases the expression of downstream molecules WASF3 and Arp2/3, suppresses tumor cell migration, reduces metastasis and prolongs survival via upregulation of its target gene, 6/November/2017, 11.06 pm

The known anti-hypertensive agent Candesartan may safeguard your heart against cardiac dysfunction:  Candesartan,, an angiotensin II receptor blocker, decreases tumor suppressor Mir-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up-regulation of its target gene, 6/November/2018, 10.40 pm
November 6, 2018
Cancer therapy targeting cancer stem cells in chronic myelogenous leukemia (CML) and other metastatic cancers: Misoprostol, an FDA-approved EP4 agonist and abortion-promoting drug, increases the expression of tumor suppressor genes, such as IGFBP3, PIAS3, p53, and TA-p73/p63, targets CML leukemic stem cells, confers protection against CML and prolongs survival, via up-regulation of its target gene, 6/November/2018,11.28 pm
November 6, 2018
Show all

Introduction: What they say:

A study from Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland 21218, USA; Johns Hopkins Physical Sciences-Oncology Center, The Johns Hopkins University, Baltimore, Maryland 21218, USA; and Department of Oncology and Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA shows that “Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration.” This study was published, in the 26 May issue of the journal “Nature communications” [One of the best journals in General Biology with an I.F of 11.329 plus], by  Prof. and Director of Physical Sciences-Oncology Center (The Johns Hopkins University) Denis Wirtz, Hasini Jayatilaka, and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Probiotic-based therapy for cancer metastasis: Probiotic Lactobacillus Rhamnosus inhibits the expression of IL-6/8, decreases the expression of downstream molecules WASF3 and Arp2/3, suppresses tumor cell migration, reduces metastasis and prolongs survival via upregulation of its target gene


From significance of the study to Public health relevance:

Given that: (i) each year nearly 14 million people are diagnosed with cancer globally; (ii) metastasis is common to all forms of cancers; (iii) metastasis is the principle reason for most of the cancer deaths; (iv) even intense multimodal treatment saves only less than 50% of metastatic patients; (iv) our understanding is incomplete in terms of down stream molecular targets and the oncogenic/malignant pathways involved in metastatic cancers; (v) cancer deaths globally are expected to be doubled in the next decade; (vi) cancer treatment causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a way to activate patients’ immune system against metastatic tumors (Cancer immunotherapy); (ii) anti-cancer drugs that target cancer stem cells that aid in tumor relapse and resistance; (iii) anti-cancer drugs that target cell adhesion molecules that aid in metastatic spread; (iv) a cheaper alternative to the existing expensive anticancer drugs; (v) a side-effect-free natural product-based drug; (vi) increase the therapeutic index of anti-cancer drugs; and (vii) a way to effectively treat and prevent metastatic progression and relapse of advanced/drug-resistant cancers.


What we infer from what they say:

Prof. Wirtz’s research team has recently shown that:(1) Interleukin-6 (IL-6) and Interleukin-8 (IL-8) are amplified by cell proliferation and cell density; (2) IL-6 and IL-8 are overexpressed only in metastatic human sarcoma and carcinoma cells, but not in normal cells: (3) increased levels of IL6 and IL-8 may increase the expression of oncogenic WASF3 and Arp2/3 and promote tumor cell migration; promote metastatic capacity of cancer cells; and (4) inhibiting the expression of IL6 and IL8, by treating the metastatic tumors with Tocilizumab and Reparaxin, stalled the metastatic progression, but not the primary tumor growth, suggesting that simultaneous inhibition of IL-6 and IL-8 may inhibit initiation of metastatic process.

 


From research findings to therapeutic opportunity :

This study suggests a probiotic-based therapy for cancer metastasis. Lactobacillus Rhamnosus, by decreasing the expression of its target genes, it may decrease the expression of both interleukins, IL-6 and IL-8 (fig. 1). Thereby, it may: (i) inhibit WASF3 and Arp2/3 expression; (ii) stifle tumor cell migration; (iii) decrease metastatic capacity of cancer cells; (iv) dismantle IL6/IL-8-WASF-Arp2/3 signaling network; (v) reduce metastasis; and (vi) promote survival (figs.1-2).

Figure 1. Mechanistic insights into how probiotic Lactobacillus Rhamnosus suppresses the expression of IL-6/8 and WASF3 and Arp2/3 to stall cancer metastasis.

Figure 2. Lactobacillus Rhamnosus functions as an anti-cancer agent through down regulation of WASF3 and Arp2/3

Thus, pharmacological formulations encompassing “Lactobacillus Rhamnosus, either alone or in combination with other known anticancer drugs” may be used to inhibit the metastatic progression of cancers.
[easy_payment currency=”USD”]


Details of the Research findings:

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Amount: $500#

Undisclosed mechanistic information: How does probiotic Lactobacillus Rhamnosus decrease the expression of IL-6/8, WASF3 and Arp2/3?

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

For purchase and payment details, you may reach us at info@genomediscovery.org

#Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com/

Citation: Boominathan, L., Probiotic-based therapy for cancer metastasis: Probiotic Lactobacillus Rhamnosus inhibits the expression of IL-6/8, decreases the expression of downstream molecules WASF3 and Arp2/3, suppresses tumor cell migration, reduces metastasis and prolongs survival via upregulation of its target gene, 6/November/2017, 11.06 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite, Kindly drop us a line at admin@genomediscovery.org

Comments are closed.