December 31, 2018

Natural product-based Anti-ageing and Life extension therapy:  A pharmaceutical mixture encompassing Piperlongumine and Quercetin increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels and enhances lifespan, via down regulation of its target gene, 31/December/2018, 7.35 pm

Introduction: What they say A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str.  Bonn, Germany; and Institute for Genetics and CECAD Research Center, […]
December 31, 2018

Probiotic-based chemotherapy targeting immune-inhibitory receptors and cancer stem cells in chronic myelogenous leukemia (CML) and other metastatic cancers: A pharmaceutical mixture encompassing  Misoprostol, an FDA-approved EP4 agonist and abortion-promoting drug, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as KIPRA, PTPN14, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets CML leukemic stem cells, confers protection against CML and prolongs survival, via up-regulation of its target gene, 31/December/2018, 7.04 pm

Introduction: What they say: A study from the Department of Microbiology and Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA shows […]
December 31, 2018

Molecular therapy for aging-associated diseases and Lifespan extension: Nicotinamide riboside, a pyridine-nucleoside form of vitamin B3 and precursor to NAD+, increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging, via down-regulation of its target gene, 31/December/2018, 6.55 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
December 28, 2018

Molecular therapy for diabetes (TIDM): Ramipril (trade names: Altace, Prilace Novapril, Ramitens, Ampril, Corpril, Piramil, Prilinda and others),), a drug used in the treatment of hypertension and cardiac dysfunction, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 28/December/2018, 11.25 pm

Introduction: What they say A study from the Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, […]