Life-extension therapy: Troglitazone (brand name: Rezulin, Resulin, Romozin, Noscal), an anti-diabetic and anti-inflammatory drug,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 25/December/2018, 5.55 pm

Molecular therapy for heart regeneration and repair: Carvidiol (trade name: Coreg), used to treat congestive heart failure and high blood pressure, increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 24/December/2017, 10.38 am
December 24, 2018
Probiotic-based Life-extension therapy: Probiotic lactobacillus reuteri  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 25/December/2018, 10.26 pm
December 25, 2018
Show all

What they say:

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science”           (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Life-extension therapy: Troglitazone (brand name: Rezulin, Resulin, Romozin, Noscal), an anti-diabetic and anti-inflammatory drug,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span



Research findings to Therapeutic opportunity: 

Troglitazone, by  increasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).

Figure 1. Mechanistic insight into how Troglitazone may extend lifespan. Troglitazone inhibits p70 S6 kInase expression and promotes longevity

[easy_payment currency=”USD”]

Thus, pharmacological formulations encompassing “Troglitazone or its analogs, either alone or in combination with any of the known longevity-promoting compound(s),” may be used to extend the lifespan of an individual (fig. 1).


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic Information: How does troglitazone decrease the expression of p70 S6 Kinase? 

# Research cooperation

Amount: $100#

For purchase and payment information, you may reach us at info@genomediscovery.org


References:

CitationBoominathan, L., Life-extension therapy: Troglitazone (brand name: Rezulin, Resulin, Romozin, Noscal), an anti-diabetic and anti-inflammatory drug,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 25/December/2018, 5.55 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.