Probiotic-based therapy for Metastatic cancers: Probiotic Lactobacillus rhamnosus decreases the expression of metastasis promoters ZBTB2 and PPM1F, inhibits cell cycle progression, and suppresses migration, invasion, and metastasis of cancer cells, via up regulation of its target gene, 5/December/2018, 10.44 pm
From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) most of the cancer patients die due to metastasis; (iv) cancer treatment causes […]
Probiotic-based adjunctive therapy for Malaria: Probiotic Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) increases Ferroportin expression, decreases intracellular iron accumulation, inhibits cellular damage, prevents hemolysis, and inhibits malaria infection, via upregulation of its target gene, 5/December/2018, 9.35 pm
Introduction: What they say: A study from the Section on Human Iron Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA shows that “Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk.” This study was published, in the 30 March 2018 issue of […]
Probiotics as anti-infective agents: Probiotics-based adjunct therapy for viral and bacterial infections: Probiotic Lactobacillus Rhamnosus GG CGMCC 1.2134 (LGG) inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1, respiratory syncytial, Sindbis, and SFV viruses by increasing the Levels of the antiviral Proteins IFITM3, & Interferon-stimulated gene, 5/December/2018, 2.40 pm
Introduction: What they say: A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA shows that “The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.” This study was published, in the 24 December 2009 issue of the […]
Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced ovarian cancer and other metastatic cancers: A pharmaceutical mixture encompassing Olaparib, an FDA-approved poly (adenosine diphosphate-ribose) polymerase inhibitor, and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as KIBRA, p57Kip2, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets ovarian cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 5/December/2018, 2.29 pm
Introduction: What they say: A study from the Stephenson Cancer Center at the University of Oklahoma, Oklahoma City (K.M.); University of Milan-Bicocca, European Institute of Oncology Istituto di Ricovero e Cura a Carattere Scientifico, Milan (N.C.), and Fondazione Policlinico Universitario A. Gemelli IRCCS Università Cattolica, Rome shows that “Maintenance Olaparib in Patients with Newly Diagnosed […]
A probiotic-based therapy for Metastatic cancers: Probiotic Lactobacillus Rhamnosus decreases the expression of PPM22 and inhibits migration, invasion and metastasis of cancer cells via up-regulation of its target gene, 5/December/2017, 2.18 pm
From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) most of the cancer patients die due to metastasis; (iv) cancer treatment causes […]
A probiotic-based immune enhancement therapy: Probiotic Lactobacillus Brevis increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 5/December/2018, 2.02 pm
Introduction: What they say: A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published, in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973], by […]
