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Probiotics function as anti-HIV agents: Probiotic Lactobacillus casei strain shirota (LcS) increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 2/December/2018, 12.15 am

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What we say:

Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Probiotics function as anti-HIV agents: Probiotic Lactobacillus casei strain shirota (LcS) increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene

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From Significance of the study to Public health relevance:

Given that: (1) more than 37 million people worldwide are living with HIV/AIDS; (2) there is no effective vaccine available for HIV/AIDS; (3) HIV/AIDS tops the list of incurable diseases in humans; (4) the life-long painful drug treatment is required to treat HIV/AIDS and its associated opportunistic infections; (5) the global economic cost spent for HIV treatment is enormous, there is an urgent need to find: (i) a way to restore CD4 T-cells that were lost in HIV/AIDS; (ii) a cheaper alternative to the existing expensive antiviral drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, HIV-1/AIDS.


Research findings to Therapeutic opportunity:

A number of studies suggest that probiotics may protect against a number of bacterial infections. However, the mechanism of action remains unclear. I had published earlier that probiotics may function as anti-infective agents–presented with detailed mechanistic insights– against a number of bacterial and viral infections.

This study suggests a probiotic-based antiviral therapy against RNA viruses such as HIV-1. Lactobacillus casei strain shirota (LcS), by increasing the expression of its target gene, it may increase the expression of Heme oxygenase-2 (HO-2) (Figure 1). Thereby, it may: (1) bind and block the myristate moiety of HIV-1 Gag protein; (2) disrupt HIV-1 budding; (3) restrict HIV-1 infectivity, replication, and production; (4) promote clearance of HIV-1 and MLV virions; and (5) strengthen antiviral immunity against RNA viruses (fig.2). Thus, Probiotic Lactobacillus casei strain shirota, either alone or in combination with other drugs,” may be used to inhibit HIV-1 production. Together, this study suggests that: (1) Lactobacillus casei strain shirota (LcS) may function as an anti-retroviral agent against HIV infections, and (2) daily intake of Probiotic Lactobacillus casei strain shirota (LcS) may protect against HIV1 infections.

Figure 1 Mechanistic insights into how probiotic Lactobacillus casei strain shirota (LcS) functions as an anti-HIV agent. Lactobacillus casei strain shirota (LcS) inhibits HIV-1 budding and production via up-regulation of its target gene HO-2

Figure 2. Lactobacillus casei strain shirota (LcS) functions as an anti-HIV agent.through induction of its target gene HO-2

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Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does probiotic Lactobacillus casei strain shirota (LcS) increase the expression of Heme oxygenase-2 (HO-2)?

Amount: $500#

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References:

Web: http://genomediscovery.org or http://newbioideas.com/

Citation: Boominathan, L., Probiotics function as anti-HIV agents: Probiotic Lactobacillus casei strain shirota (LcS) increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 2/December/2018, 12.14 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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