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Probiotic-based chemotherapy for “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: A pharmaceutical composition encompassing Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, and Lactobacillus Rhamnosus increases the expression of tumor suppressors genes, such as PTPN14, p12DOC1, TA-p73/p63, p53 and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene , 6/December/2018, 3.24 pm

Hot water immersion therapy for lowering cholesterol, and triglycerides levels: Hot water immersion (at 39C for 1 hour) decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 6/December/2018, 3.09 pm
December 6, 2018
A sweet way to treat Metastatic cancers: Xylobiose, a disaccharide of xylose, increases the expression of tumor/metastatic suppressors LATS1 and SMARCD4, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up-regulation of its target gene, 6/December/2018, 10.38 pm
December 6, 2018
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From Significance of the study to Public health relevance

Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our understanding is incomplete in terms of molecular targets and the oncogenic/malignant pathways involved in mutant p53-overexpressing tumors; (4) cancer causes the highest economic loss compared to all the known causes of death worldwide; and (5) cancer causes the considerable economic loss worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; and (iii) a way to effectively treat and stall metastatic progression and relapse of mutant p53-overexpressing human cancers.


From therapeutic strategy to Research Findings:

(i) Therapeutic strategy: 

This study suggests a therapeutic strategy for stalling the progression of p53-deficient/deleted or mutant-p53 expressing metastatic cancers. By activating tumor suppressor p53’s unmutated “homologous protein such as TAp73/p63” in p53-deficient or mutant-p53 expressing metastatic cancer cells, one can stall their progression.

(ii) Research findings:  

A number of studies suggests that the valsartan functions as an anticancer agent. However, the mechanism of action is far from clear.

This study suggests, for the first time, that valsartan, by decreasing the expression of its target gene, it may increase the expression of tumor suppressors genes, such as PTPN14, p12DOC1, TA-p73/p63α,  p53 and others. Thereby, it may inhibit the migration and invasion of metastatic cancer cells expressing mutant-p53 (figure1).

Figure 1. Mechanistic insight into how valsartan functions as an anticancer/antimetastatic agent in mutant p53-expressing tumors.  Valsartan,  by activating tumor suppressor genes, such as PTPN14, p12DOC1, TAp73/p63α, p53 and others, in metastatic tumors, it may inhibit the progression of mutant-p53 expressing human cancers.

Figure 2. Valsartan functions as an antimetastasis agent through induction of PTPN14 and p12DOC1

Figure 3. A pharmacological formulation encompassing “Valsartan and the probiotic  Lactobacillus rhamnosus” may be used to inhibit the progression of metastatic cancers

 


Therapeutic opportunity:

Given the ability of valsartan to induce the expression of a number of tumor suppressor genes, pharmacological formulations encompassing valsartan or its analogs, either alone or in combination with other anticancer drugs, may be used to inhibit the progression of p53-mutated invasive metastatic tumors (Figure 2). 

Further, the efficacy of valsartan can be increased by treating cancer patients with a pharmaceutical mixture encompassing valsartan and the probiotic Lactobacillus rhamnosus  (1.0×103 CFU/ml) (Figure 3). Taken together, this study suggests that oncologists may consider treating terminally ill metastatic cancer patients with valsartanto stall the progression of advanced metastatic cancers (Figure 3).


Details of the research findings

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $300#

Undisclosed mechanistic information: How valsartan increases the expression of tumor suppressor genes, such as PTPN14, p12DOC1, and others,  in mutant p53 expressing cancer cells?

For purchase and payment details, you may reach us at admin@genomediscovery.org

#Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., Probiotic-based chemotherapy for “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: A pharmaceutical composition encompassing Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, and Lactobacillus Rhamnosus increases the expression of tumor suppressors genes, such as PTPN14, p12DOC1, TA-p73/p63, p53 and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 6/December/2018, 3.24 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

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