Repurposing the anti-hypertensive agent Telmisartan into an anti-diabetic agent:  Telmisartan (brand name: Micardis), an antihypertensive agent, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 8/January/2018, 10.29 pm

RNA-based therapy for Diabetic retinopathy: A pharmaceutical mixture encompassing  lncRNA TUG1, Epicatechin and Matrine (TUG1EM)  inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 5/January/2018, 12.04 am
January 4, 2019
Ribonucleic acid-based therapy for TIIDM and obesity-associated metabolic deficits: LncRNA TUG1 increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM, via down-regulation of its target gene, 8/January/2019, 10.43 pm
January 8, 2019
Show all

IntroductionWhat they say:  

A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published, in the 30 September  2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of 28.71],  by Prof and Dean of the Harvard Medical School George Q, Zhu H, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports that:   Repurposing the anti-hypertensive agent Aliskiren into an anti-diabetic agent:  Telmisartan (brand name: Micardis), an antihypertensive agent, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28


From significance of the study to Public health relevance: 

Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) Diabetes is going to be one of the top 10 causes of death by 2030; (3) the life-long painful injection/drug treatment is required to treat DM; (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells and cardiomyocytes that were lost in DM (Diabetes Mellitus) and MI (Myocardial infarction), respectively; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.


What is known?

Prof. George Q and his research team members had shown earlier that loss of Lin28 in muscles promotes insulin resistance and glucose intolerance. 


From Research findings to Therapeutic opportunity:

This study provides, for the first time, mechanistic insight into how Telmisartan may protect against diabetes.

This study suggests that Telmisartan, by increasing the expression of its target gene, it may (1) increase the expression of IGF1R, INSR, and IRS2; (2) enhance tissue repair; (3) promote regeneration of pancreatic β-cells; (3) augment regenerative capacity; (4) promote insulin sensitivity; and (5) protect against dilated cardiomyopathy (DCM) (Fig.1).

Figure 1. Mechanistic insights into how Telmisartan (brand name: Micardis) functions as an anti-diabetic and a cardioprotective agent. Rivaroxaban may promote insulin sensitivity and protect against myocardial infarction via up regulation of reprogramming protein Lin-28

Figure 2. Telmisartan functions as an anti-diabetic agent through induction of Lin-28

 

Thus, pharmacological formulations encompassing “Telmisartan or its analogs, either alone or in combination with other drugs,” may be used to treat DM and DCM.

[easy_payment currency=”USD”]


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $ 100#

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Telmisartan promote insulin-sensitized state?

# Research cooperation


References

Web: http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan L, Repurposing the anti-hypertensive agent Aliskiren into an anti-diabetic agent:  Telmisartan (brand name: Micardis), an antihypertensive agent, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 8/January/2018, 10.29 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.