The erectile dysfunction drug sildenafil may protect against Myocardial Infarction: Sildenafil (brand name: viagra), a PDE5 inhibitor used in the treatment of erectile dysfunction and pulmonary hypertension, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 16/January/2019, 11.55 pm

RNA-based therapy for aging-associated diseases and Lifespan extension: LncRNA HULC  inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer and aging, via down-regulation of its target gene, 16/January/2019, 11.33 pm
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What they say

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of the journal Nature,  by Prof Dimmler, Boon, and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  The erectile dysfunction drug sildenafil may protect against Myocardial Infarction: Sildenafil (brand name: viagra), a PDE5 inhibitor used in the treatment of erectile dysfunction and pulmonary hypertension, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS


price-300[easy_payment currency=”USD”]

From Significance of the study to Public Health Relevance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from  123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.


From Research Findings to Therapeutic Opportunity

This study suggests, for the first time, that Sildenafil may protect against myocardial infarction. Sildenafil, by increasing the expression of its target genes, it may increase the expression of PNUTS (fig.1). Thereby, it may: (1) inhibit DNA damage responses, (2) increase telomerase expression, (3) inhibit telomere shortening; (4) promote cardiomyocyte survival/regeneration; (5) decelerate aging; and (6) extend lifespan (fig 1). 

Figure 1.  Mechanistic insights into how LncRNA 015192  induces the expression of PNUTS and Telomerase to prevent myocardial infarction and promote Cardiac regeneration/survival

Figure 2. Sildenafil  functions as a cardioprotective agent through induction of PNUTS

Together, this study suggests that pharmacological formulations encompassing“Sildenafil  or its analogs, either alone or in combination with other drugs,” may be used to improve cardiac function after myocardial infarction (fig. 2).  


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Sildenafil   increase the expression of PNUTS/Telomerase?

Amount: $300#

# Research cooperation

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References

Web:http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan, L., The erectile dysfunction drug sildenafil may protect against Myocardial Infarction: Sildenafil (brand name: viagra), a PDE5 inhibitor used in the treatment of erectile dysfunction and pulmonary hypertension, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 16/January/2019, 11.55 pm,  Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

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