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February 5, 2019

Ribonucleic acid-based therapy for TIIDM and obesity-associated metabolic deficits: LncRNA  H19 increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM, via down-regulation of its target gene, 5/February/2019, 10.33 pm

Introduction: What they say A study from the Department of Physiology-Cellular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York, USA shows that “MC4R-dependent […]
February 5, 2019

Probiotic-based therapy for body weight control, energy homeostasis, and TIIDM: Probiotic Clostridium butyricum MIYAIRI 588 (CBM588)  increases REV-ERB and its downstream target genes, inhibits lipid accumulation, improves dyslipidemia and insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 5/February/2019, 10.17 pm

Introduction: What they say A study from the Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA shows that “Regulation of circadian behaviour […]
February 5, 2019

Ribonucleic acid-based therapy for cardiac hypertrophy and fibrosis: lncRNA PCGEM  decreases MiR-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 5/January/2019, 10.06 pm

Introduction: What they say: A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]
February 5, 2019

Combinatorial therapy for brain tumor and oesophageal squamous cell carcinoma:  A therapeutic mix encompassing metformin and navitoclax/ABT263 (MAN) inhibits the expression of Integrin a7 (ITGA7), impairs laminin-induced/FAK-mediated signalling, inhibits the proliferation of glioblastoma and oesophageal squamous cell carcinoma stem cells, suppresses tumor cell migration, reduces metastasis and prolongs survival, via down-regulation of its target gene, 5/February/2019, 6.21 am

Introduction: What they say: A study from the Institute of General Pathology, Università Cattolica del Sacro Cuore and Fondazione Policlinico Universitario A. Gemelli, 00168 Rome, Italy; […]