Probiotics-based immune enhancement therapy: A Probiotic mixture encompassing Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (LBLC)  increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 28/February/2019, 8.46 am

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National Science day special

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We wish everyone a very happy national science day. On this special occasion, we are happy to announce that Bio-Med/Pharma/Therapeutic/Clinical ideas posted today (28/February/2019) will be available to the use of Scientists/Professors/Faculties/Teachers/Physicians/Researchers for free. So, there will be no terms and conditions for the ideas posted today. Each idea posted will be served first come, first serve basis. Write to admin@genomediscovery.org for more details.

Dr L Boominathan PhD

President, Director & CSO, GBMD.

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Introduction: What they say:  

A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published, in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of  24.973], by Drs. Zusen Fan, Xia and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that: Probiotics-based immune enhancement therapy: A Probiotic mixture encompassing Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (LBLC)  increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene


From Research Findings to Therapeutic Opportunity:

This study suggests, for the first time, a Probiotic mixture encompassing Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (LBLC)by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in the cytoplasm; and (3) promote innate immunity against bacterial infection. 

Figure 1. Probiotic-based immune enhancement therapy. Probiotic Lactobacillus reuteri, by increasing the expression of its target genes, it increases the expression of Sox-2 and its downstream components in the signaling pathway. And, thereby, promotes anit-bacterial immunity.

Figure 2. Probiotic Lactobacillus reuteri may increase resistance against bacterial infection through induction of Sox2

Together,pharmacological formulations encompassing “Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (LBLC),  either alone or in combination with other drugs,” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance (figs. 1-2). 


Details of the research findings

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does a probiotic mixture encompassing Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (LBLC) enhance innate immunity against bacterial infections?

Amount: $750

# Research cooperation

For purchase and payment details, you may reach us at info@genomediscovery.org


References:

CitationBoominathan, L., Probiotics-based immune enhancement therapy: A Probiotic mixture encompassing Lactobacillus plantarum KY1032 and Lactobacillus curvatus HY7601 (LBLC)  increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 28/February/2019, 8.46 am,  Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com/

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