Probiotic Lactobascillus Gasseri functions as a longevity promoter: Lactobascillus Gasseri may  increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes, 24/February/2019, 11.58 pm

Ribonucleic acid-based therapy for Diabetes Mellitus: LncRNA CCAT2  augments the expression of FGF19 and FGF1,  attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM via upregulation of its target gene, 24/February/2019, 11.25 pm
February 24, 2019
Combinatorial therapy targeting PD-L1 pathway enhances the efficacy of Cancer immunotherapy in Glioblastoma: A therapeutic mix encompassing   Metformin, Navitoclax/ABT-263, Dasatinib and 2-Deoxy-d-glucose (MNDDG) inhibits oncoproteins EGFR, and Bcl-xl expression, increases tumor suppressor p53 expression, inhibits glioblastoma proliferation, increases interferon-IFNγ signalling, increase antigen presentation and unfolding response, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival, via up-regulation of its target gene, 25/February/2019, 12.17 pm
February 24, 2019
Show all

 What they say: Introduction: 

A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July  2014 issue of the journal  “EMBO”, by Prof Sinclair, North BJ, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Probiotic Lactobascillus Gasseri functions as a longevity promoter: Lactobascillus Gasseri may  increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes

 


From research findings to Therapeutic Opportunity: 

This study suggests, for the first time, that Probiotic Lactobascillus Gasseriby increasing the expression of its target gene, may: (a) increase the expression of BuBR1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase); (b) decrease the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (fig. 1). Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue rejuvenation; and (7) prolong median lifespan.

Figure 1. Probiotic Lactobascillus Gasseri functions as a longevity promoter.  Probiotic Lactobascillus Gasseri   may extend  mammalian lifespan via up-regulation of BuBR1; and down-regulation of p70 S6 Kinase

Figure 2. Probiotic Lactobascillus Gasseri  functions as a longevity-promoter through induction of BuBR1.

Thus, a pharmaceutical mixture encompassing Probiotic Lactobascillus Gasseri, either alone or in combination with other drugs, may be used to extend the lifespan of an individual (fig.2).

[easy_payment currency=”USD”]


Details on the research findings: 

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Amount: $750#

Undisclosed mechanistic information: How does Probiotic Lactobascillus Gasseri increase the expression of BubR1?

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation


References

Web: http://genomediscovery.org or http://newbioideas.com

CitationBoominathan, L., Probiotic Lactobascillus Gasseri functions as a longevity promoter: Lactobascillus Gasseri may  increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes, 24/February/2019, 11.58 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at admin@genomediscovery.org

Comments are closed.