Ribonucleic acid-based therapy for glaucoma: LncRNA TUG1 increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma, via down regulation of its target gene, 13/March/2018, 5.26 am
Introduction: What they say A study from the The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Ophthalmology, Tufts University of Medicine, Boston, MA 02111, USA; The Howard Hughes Medical Institute, Bar Harbor, ME 04609, USA shows that “Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice.” This research paper was published, […]
Repurposing the antihyperlipidemic drug Atorvastatin into an anti-HIV agent: Atorvastatin (trade name: Lipitor), a medication prescribed to lower cholesterol and triglyceride, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene, 12/March/2019, 9.51 am
What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Repurposing the antihyperlipidemic drug Atorvastatin into an anti-HIV agent: Atorvastatin (trade name: Lipitor), a medication prescribed to lower cholesterol and triglyceride, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production, via upregulation of its target gene […]
Probiotic-based immune enhancement therapy: Probiotic Clostridium butyricum MIYAIRI 588 (CBM588) increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 12/March/2019, 9.41 am
Introduction: What they say: A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published, in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973], by […]
Ribonucleic acid-based therapy for Diabetes Mellitus: LncRNA H19 augments the expression of FGF19 and FGF1, attenuates hepatic glucose production, decreases hepatic acetyl CoA content, brings down the levels of plasma ACTH, and corticosterone, augments insulin sensitivity, promotes weight loss and alleviates TIDM, via upregulation of its target gene, 12/March/2019, 9.27 am
Introduction: What they say A study from Diabetes and Obesity Center of Excellence, Department of Medicine, University of Washington, Seattle, Washington, USA shows that Central injection of FGF1 induces sustained remission of diabetic hyperglycemia in rodents. This research paper was published, in the 23 May 2016 issue of the journal “Nature Medicine” [One of the […]
Ribonucleic acid-based therapy for enhancing memory and cognition: LncRNA PVT1 increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 12/March/2019, 9.18 am
Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA; Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California 94305, USA; Center for Tissue […]
Ribonucleic acid-based pain medication therapy: LncRNA TUSC7 increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 12/March/2018, 8.49 am
Introduction: What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China; and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, US shows that “PD-L1 inhibits acute and chronic pain by suppressing nociceptive […]