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April 22, 2019

Mechanistic insights into how Edaravone aids in recovery from stroke: Edaravone (brand name: Radicut, Radicava, Xavron, Edavit, others), used in the treatment of stroke and amyotrophic lateral sclerosis, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 23/April/2019, 12.14 am

Introduction: What they say: A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center […]
April 22, 2019

Mechanistic insights into how bariatric surgery aids in control of body weight, energy homeostasis, and TIIDM: Bariatric surgery increases REV-ERB and its downstream target genes, inhibits lipid accumulation, improves dyslipidemia and insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 22/April/2018, 11.35 pm

Introduction: What they say A study from the Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA shows that “Regulation of circadian behaviour […]
April 22, 2019

Molecular therapy for cardiac dysfunction: Canagliflozin (trade name: Invokana), a medication used to treat hyperglycemia, decreases Mir-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function, via upregulation of its target gene, 22/April/2018, 10.31 pm

Introduction: What they say:   A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]
April 22, 2019

Ribonucleic acid-based therapy protects against and promotes functional recovery after Myocardial Infarction:  LncRNA Mirt2 inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of its target gene, 22/April/2019, 10.10 pm

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of […]