Eat oats to stay free of infections caused by chikungunya (CHIKV) and Zika (ZIKV) viruses: Oats-based antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Avenanthramide-A, derived from Oats, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication, via upregulation of its target gene, 6/April/2019, 12.43 pm

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing a pharmacological formulation encompassing Metformin, Navitoclax/ABT-263, & Dasatinib (MND) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as  BIRC5, PIAS3, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 5/April/2019, 11.14 pm
April 5, 2019
Ribonucleic acid-based therapy for enhancing memory and cognition: LncRNA CAR10 increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target genes, 6/April/2019, 12.48 pm
April 6, 2019
Show all

Introduction: What they say

A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows thatInterferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses.”  This research paper was published, in the 10 August 2016 issue of the journal “Cell Host and microbe” [One of the best research journals in Infectious biology with an I.F of 12.552], by Prof. Marco Vignuzzi, Bryan C. Mounce and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that:   Eat oats to stay free of infections caused by chikungunya (CHIKV) and Zika (ZIKV) viruses: Oatsbased antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Avenanthramide-A, derived from Oats, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication, via upregulation of its target gene


What is known?

Prof. Marco Vignuzzi’s research team has recently shown that induction of type I interferon results in: a) upregulation of SAT1; b) depletion of spermidine and spermine levels; and c) inhibition of Chikungunya and Zika viruses production. They have further validated this by showing that exogenous administration of Polyamines (spermidine and spermine) restores virus replication.


From research findings to Therapeutic opportunity:

This study suggests, for the first time, an Oat meal-derived compound Avenanthramide-A may attenuate diseases caused by Chikungunya virus (CHIKV) and Zika virus (ZIKV).  Avenanthramide-A, by increasing the expression of its target gene, it may increase the expression of spermidine/spermine N1-acetyltransferase (SAT1) (Figure 1). Thereby, it may: (1) decrease polyamine spermidine and spermine levels; (2) stall CHIKV and ZIKV replication; (3) promote clearance of Zika and Chikungunya Viruses; and (4) strengthen antiviral immunity against RNA viruses. (Figure 2)

Figure 1 Mechanistic insights into how Avenanthramide-A functions as an antiviral agent. Avenanthramide-A inhibits the replication of Chikungunya and Zika viruses through induction of SAT

Figure 2.Avenanthramide-A functions as an anti-viral agent against CHIKV/ZIKV viruses.

Thus, pharmacological formulations encompassing “Avenanthramide-A or its analogs, either alone or in combination with other drugs”, may be used to treat infections caused by chikungunya (CHIKV) and Zika (ZIKV) viruses. Given that Ciprofloxacin is more economical compared with other antiviral drugs, it may find a larger utility in patient care as a broad-spectrum anti-viral/infective agent. 


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Avenanthramide-A decrease the expression of spermidine/spermine N1-acetyltransferase (SAT1)?

Amount: $ 500#

For payment and purchase details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L,  Eat oats to stay free of infections caused by chikungunya (CHIKV) and Zika (ZIKV) viruses: Oatsbased antiviral therapy for chikungunya (CHIKV) and Zika (ZIKV) viruses: Avenanthramide-A, derived from Oats, increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication, via upregulation of its target gene, 6/April/2019, 12.43 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite, drop us a line at admin@genomediscovery.org

Comments are closed.