Embryo-derived peptide augments memory, learning, and cognition: Synthetic PreImplantation Factor (sPIF), a peptide derived from embryos, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, improves cognition, and attenuates age-associated decline in memory and learning, via up-regulation of its target genes, 25/April/2018, 6.31 am

Caloric restriction aids in the treatment of stroke and other neurological deficits:  Caloric restriction attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 25/April/2019, 5.58 am
April 25, 2019
Nucleostemin-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Nucleostemin, a nucleolus protein known to play a role in cell cycle progression, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 25/April/2019, 6.54 am
April 25, 2019
Show all

Introduction: What they say

A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California 94305, USA; Center for Tissue Regeneration, Repair and Restoration, V.A. Palo Alto Healthcare System, Palo Alto, California 94304, USA shows that “Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.” This research paper was published, in the 19 April 2017 issue of the journal “Nature” [One of the best research journals in General sciences with an I.F of 43+], by Prof.Tony Wyss-Coray, Joseph M. Castellano and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Embryo-derived peptide augments memory, learning, and cognition: Synthetic PreImplantation Factor (sPIF), a peptide derived from embryos, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, improves cognition, and attenuates age-associated decline in memory and learning, via up-regulation of its target genes


What is known?

Prof.Tony Wyss-Coray’s research team has recently shown that:  (1) human cord plasma treatment promotes cognitive and learning function in aged mice; (2) blood-borne component Tissue inhibitor of metalloproteinases 2 (TIMP2) is enriched in human cord plasma, young mouse plasma, and young mouse hippocampi; (3) TIMP2 increases hippocampal-dependent cognition; and (4) treating brain slices with TIMP2 antibody inhibits long-term potentiation and prevents hippocampal function, suggesting that increasing the expression of TIMP2 in aged individuals may enhance learning and memory.


 

From Research findings to Therapeutic opportunity:

This study suggests, for the first time, that PreImplantation Factor (sPIF), derived from viable embryos, augments cognition,  memory, and learning. Synthetic PreImplantation Factor (sPIF), by increasing the expression of its target genes, may decrease the levels of TIMP2 and BDNF (fig.1). Thereby, it may: (1) attenuate cognition and learning; (2) diminish spatial memory; and (3)  deteriorate hippocampal function (fig.2).

Figure1. Mechanistic insights into how  PreImplantation Factor (PIF) augments learning, memory, and cognition.  Synthetic PreImplantation Factor (sPIF), by decreasing the expression of TIMP2, it increases learning and memory in aged individuals.

Figure 2. Synthetic PreImplantation Factor (sPIF) injection enhances learning, memory, and cognition through down-regulation of TIMB2 and BDNF

Thus, pharmacological formulations encompassing Synthetic PreImplantation Factor or its mimics, either alone or in combination with other drugs, may be used to enhance learning, memory, and cognition. 


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Synthetic PreImplantation Factor (sPIF) increase the levels of TIMP2 and BDNF?

Amount: $500#

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L.,  Embryo-derived peptide augments memory, learning, and cognition: Synthetic PreImplantation Factor (sPIF), a peptide derived from embryos, increases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, improves cognition, and attenuates age-associated decline in memory and learning, via up-regulation of its target genes, 25/April/2018, 6.31 am, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite, drop us a line at admin@genomediscovery.org

Comments are closed.