Empty-stomach intelligence is explained: Mechanistic insights into how hunger hormone Ghrelin augments augments memory, learning, and cognition:  Ghrelin, a digestive hormone that controls appetite,  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, improves cognition, and attenuates age-associated decline in memory and learning, via up-regulation of its target genes, 28/April/2018, 12.17 am

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Introduction: What they say

A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California 94305, USA; Center for Tissue Regeneration, Repair and Restoration, V.A. Palo Alto Healthcare System, Palo Alto, California 94304, USA shows that “Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.” This research paper was published, in the 19 April 2017 issue of the journal “Nature” [One of the best research journals in General sciences with an I.F of 43+], by Prof.Tony Wyss-Coray, Joseph M. Castellano and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Empty-stomach intelligence is explained: Mechanistic insights into how hunger hormone Ghrelin augments augments memory, learning, and cognition:  Ghrelin, a digestive hormone that controls appetite,  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, improves cognition, and attenuates age-associated decline in memory and learning, via up-regulation of its target genes


What is known?

Prof.Tony Wyss-Coray’s research team has recently shown that:  (1) human cord plasma treatment promotes cognitive and learning function in aged mice; (2) blood-borne component Tissue inhibitor of metalloproteinases 2 (TIMP2) is enriched in human cord plasma, young mouse plasma, and young mouse hippocampi; (3) TIMP2 increases hippocampal-dependent cognition; and (4) treating brain slices with TIMP2 antibody inhibits long-term potentiation and prevents hippocampal function, suggesting that increasing the expression of TIMP2 in aged individuals may enhance learning and memory.


 

From Research findings to Therapeutic opportunity:

It is known for years that mild hunger improves cognition, learning and memory, however, the mechanism of action remains largely unclear. This study suggests, for the first time, that hunger hormone Ghrelin augments cognition,  memory, and learning. Ghrelin, by increasing the expression of its target genes, may increase the levels of TIMP2 and BDNF (fig.1). Thereby, it may: (1) augment cognition and learning; (2) improve spatial memory; and (3)  augment hippocampal function (fig.2).

Figure1. Mechanistic insights into how/why Ghrelin augments learning, memory, and cognition. Ghrelin, by increasing the expression of its target gene, increases the expression of TIMP2. And thereby it increases learning and memory in aged individuals.

Figure 2. Ghrelin enhances learning, memory, and cognition through up-regulation of TIMB2 and BDNF

Thus, a pharmaceutical mixture encompassing Ghrelin or it inducers, either alone or in combination with other drugs, may be used to enhance learning, memory, and cognition. 


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Ghrelin increase the levels of TIMP2 and BDNF?

Amount: $500#

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# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L.,  Empty-stomach intelligence is explained: Mechanistic insights into how hunger hormone Ghrelin augments augments memory, learning, and cognition:  Ghrelin, a digestive hormone that controls appetite,  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, improves cognition, and attenuates age-associated decline in memory and learning, via up-regulation of its target genes, 28/April/2018, 12.16 am, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

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