Mechanistic insights into how high fat diet may deteriorate memory, learning, and cognition: High fat diet decreases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, attenuates cognition, and aggravates age-associated decline in memory and learning, via up-regulation of its target genes, 9/April/2018, 11.41 pm

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Introduction: What they say

A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California 94305, USA; Center for Tissue Regeneration, Repair and Restoration, V.A. Palo Alto Healthcare System, Palo Alto, California 94304, USA shows that “Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.” This research paper was published, in the 19 April 2017 issue of the journal “Nature” [One of the best research journals in General sciences with an I.F of 43+], by Prof.Tony Wyss-Coray, Joseph M. Castellano and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Mechanistic insights into how high fat diet may deteriorate memory, learning, and cognition: High fat diet decreases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, attenuates cognition, and aggravates age-associated decline in memory and learning, via up-regulation of its target genes


What is known?

Prof.Tony Wyss-Coray’s research team has recently shown that:  (1) human cord plasma treatment promotes cognitive and learning function in aged mice; (2) blood-borne component Tissue inhibitor of metalloproteinases 2 (TIMP2) is enriched in human cord plasma, young mouse plasma, and young mouse hippocampi; (3) TIMP2 increases hippocampal-dependent cognition; and (4) treating brain slices with TIMP2 antibody inhibits long-term potentiation and prevents hippocampal function, suggesting that increasing the expression of TIMP2 in aged individuals may enhance learning and memory.


 

From Research findings to Therapeutic opportunity:

A number of studies suggest that  high fat diet may compromise cognition,  memory, and learning. However, the mechanism of action is far from clear. This study provides mechanistic insights into how high fat diet may compromise cognition,  memory, and learning. High fat diet, by increasing the expression of its target genes, may decrease the levels of TIMP2 and BDNF. Thereby, it may: (1) attenuate cognition and learning; (2) diminish spatial memory; and (3)  deteriorate hippocampal function (fig.1).

 

Figure1. Mechanistic insights into how  high fat diet may diminish learning, memory, and cognition.  High fat diet, by decreasing the expression of TIMP2, it decreases learning and memory in aged individuals.

Figure 2. Consumption of high fat diet declines learning, memory, and cognition through down-regulation of TIMB2 and BDNF


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How high fat diet decreases the levels of TIMP2 and BDNF and attenuates memory and learning

Amount: $500#

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# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L.,  Mechanistic insights into how high fat diet may deteriorate memory, learning, and cognition: High fat diet decreases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, attenuates cognition, and aggravates age-associated decline in memory and learning, via up-regulation of its target genes, 9/April/2018, 11.41 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

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