What they say:
A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac aging and function.” This study was published, in the 7 March 2013 issue of the journal Nature, by Prof Dimmler, Boon, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic insights into why consumption of high fact diet is bad for your heart: High fat diet promotes DNA damage responses, decreases telomerase expression, accelerates telomere shortening, and decreases cardiomyocyte survival after myocardial infarction, via downregulation of PNUTS
From Significance of the study to Public Health relevance:
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from 123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.
From Research Findings to Therapeutic Opportunity:
Consumption of high fat diet has long been shown to promote cardiac dysfunction. However, mechanistic insights into how consumption of high fat diet promotes cardiac dysfunction remains largely unclear. This study suggests that high fat diet, by increasing the expression of its target genes, it may decrease the expression of PNUTS (fig.1). Thereby, it may: (1) augment DNA damage responses, (2) decrease telomerase expression, (3) promote telomere shortening; (4) inhibit cardiomyocyte survival/regeneration; (5) accelerate aging; and (6) decrease lifespan (fig 1).
Together, this study provides mechanistic insights into how increased consumption of high fat diet may promote cardiac ageing, and increase the chances of getting myocardial infarction (fig. 2).
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does high fact diet increase the expression of PNUTS/Telomerase?
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Citation: Boominathan, L., Mechanistic insights into why consumption of high fact diet is bad for your heart: High fat diet promotes DNA damage responses, decreases telomerase expression, accelerates telomere shortening, and decreases cardiomyocyte survival after myocardial infarction, via downregulation of PNUTS, 8/April/2019, 11.38 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org
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