Neuropeptide Y-based therapy for inflammation and arthritis: Neuropeptide Y, a  36 amino-acid neuropeptide that plays a role in the regulation of food intake, storage of food, anxiety, stress, perception of pain and others, increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 29/April/2019, 3.10 pm

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Introduction: What they say

A study from Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany shows that “Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells.” This research paper was published, in the 17 July 2017 issue of the journal “Nature Medicine” [One of the best research journals in General Medicine with an I.Fs of 30.357], by Prof.Andreas Ramming, Rauber S and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:   Neuropeptide Y-based therapy for inflammation and arthritis: Neuropeptide Y, a  36 amino-acid neuropeptide that plays a role in the regulation of food intake, storage of food, anxiety, stress, perception of pain and others, increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes

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From the significance of the study to Public health relevance:

Given that: (1) Rheumatoid arthritis (RA) has caused 49,000 deaths globally in 2010; and it is likely that death due to RA may increase in the coming years; (2) RA approximately affects between 0.5% to 1% of adults in the developing world; (3) between 5 and 50 per 100, 000 people develop RA each year; (3) Women are three to five times more affected by RA than men; (4) most of the drugs that are in use today, to treat RA, treats only the symptoms, not the root cause of the disease; (5) RA is characterized by chronic joint pains; and (6) the global economic cost spent in the treatment of RA is enormous, there is an urgent need to find: (i) molecular mechanisms and the components involved in bio-pathways leading to RA; (ii) a cheaper alternative to the existing expensive drugs; and (iii) a side-effect-free Natural product-based drug that alleviates not only alleviates pain, but also cures RA.


What is known?

Prof.Andreas Ramming‘s research team has recently shown that: (1) interleukin (IL)-9-producing type 2 innate lymphoid cells (ILC2s) as mediators of chronic inflammation; (2) the lack of IL-9 production culminates in: (a) defective ILC2 proliferation and activation of regulatory T (Treg) cells; (b) arthritis; (c) excessive cartilage destruction; and (d) bone loss; (3) treatment with IL-9 results in a) resolution of inflammation; and b) protection of bone; and (4) increased numbers of IL-9+ILC2s in joints and the circulation of patients, in remission stage of rheumatoid arthritis, suggesting that IL-9-mediated ILC2 activation is a method of treatment for chronic inflammation, such as arthritis, as it promotes resolution of inflammation rather than suppression of inflammatory mediators.


From research findings to Therapeutic opportunity:

This study suggests that Neuropeptide Y may aid in the treatment of inflammatory diseases, including arthritis. Neuropeptide Y, by increasing the expression of its target gene, it may increase the expression of IL-9 and its downstream target genes. Thereby, it may: (1) increase the proliferation of ILC2s cells; (2) promote activation of Treg cells; (3) promote resolution of inflammation; (4) suppress cartilage destruction; (5) inhibit bone loss and strengthen bone structure; and (6) inhibit arthritis progression. Thus, pharmacological formulations encompassing Neuropeptide Y  or its activators, either alone or in combination with other compounds,” (fig 1), may be used to promote resolution of inflammation and inflammatory diseases, including arthritis.

 

Figure1. Mechanistic insights into how a pharmaceutical mixture encompassing Neuropeptide Y  increases IL-9 levels, promotes proliferation/activation of ILC2s/Treg cells, enhances the resolution of inflammation, stifles cartilage destruction and inhibits bone loss.

Figure 2. Neuropeptide Y protects against inflammatory diseases through induction of IL-9.

 


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $ 500#

Undisclosed mechanistic information: How Neuropeptide Y increases IL-9 levels, activates ILC2 proliferation and regulatory T (Treg) cells, inhibits cartilage destruction, and suppresses bone loss and improves arthritis.

# Research cooperation

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References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L.,  Neuropeptide Y-based therapy for inflammation and arthritis: Neuropeptide Y, a  36 amino-acid neuropeptide that plays a role in the regulation of food intake, storage of food, anxiety, stress, perception of pain and others, increases IL-9 levels, augments proliferation of ILC2s (type 2 innate lymphoid cells) and regulatory T (Treg) cells, promotes resolution of inflammation, attenuates cartilage destruction, decreases bone loss, and inhibits pathological features associated with arthritis via up-regulation of its target genes, 29/April/2019, 3.10 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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