Starve yourself a little to stay sharper during exams: Mechanistic insights into how caloric restriction augments augments memory, learning, and cognition:  Caloric restriction increases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, improves cognition, and attenuates age-associated decline in memory and learning, via up-regulation of its target genes, 25/April/2018, 7.43 am

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Introduction: What they say

A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California 94305, USA; Center for Tissue Regeneration, Repair and Restoration, V.A. Palo Alto Healthcare System, Palo Alto, California 94304, USA shows that “Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.” This research paper was published, in the 19 April 2017 issue of the journal “Nature” [One of the best research journals in General sciences with an I.F of 43+], by Prof.Tony Wyss-Coray, Joseph M. Castellano and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Starve yourself a little to stay sharper during exams: Mechanistic insights into how caloric restriction augments augments memory, learning, and cognition:  Caloric restriction increases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, improves cognition, and attenuates age-associated decline in memory and learning, via up-regulation of its target genes


What is known?

Prof.Tony Wyss-Coray’s research team has recently shown that:  (1) human cord plasma treatment promotes cognitive and learning function in aged mice; (2) blood-borne component Tissue inhibitor of metalloproteinases 2 (TIMP2) is enriched in human cord plasma, young mouse plasma, and young mouse hippocampi; (3) TIMP2 increases hippocampal-dependent cognition; and (4) treating brain slices with TIMP2 antibody inhibits long-term potentiation and prevents hippocampal function, suggesting that increasing the expression of TIMP2 in aged individuals may enhance learning and memory.


 

From Research findings to Therapeutic opportunity:

It is known for years that mild hunger improves learning, however, the mechanism of action remains largely unclear. This study suggests, for the first time, that caloric restriction augments cognition,  memory, and learning. Caloric restriction, by increasing the expression of its target genes, may increase the levels of TIMP2 and BDNF (fig.1). Thereby, it may: (1) augment cognition and learning; (2) improve spatial memory; and (3)  augment hippocampal function (fig.2).

Figure1. Mechanistic insights into how/why caloric restriction augments learning, memory, and cognition. Caloric restriction, by decreasing the expression of TIMP2, it increases learning and memory in aged individuals.

Figure 2. Caloric restriction enhances learning, memory, and cognition through up-regulation of TIMB2 and BDNF

Thus, caloric restriction or Calorie restriction mimetics, either alone or in combination with other drugs, may be used to enhance learning, memory, and cognition. 


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does calorie restriction increase the levels of TIMP2 and BDNF?

Amount: $500#

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# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L.,  Starve yourself a little to stay sharper during exams: Mechanistic insights into how caloric restriction augments augments memory, learning, and cognition:  Caloric restriction increases Tissue inhibitor of metalloproteinases 2 (TIMP2) and BDNF levels, improves cognition, and attenuates age-associated decline in memory and learning, via up-regulation of its target genes, 25/April/2018, 7.43 am, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

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