Drinking ginger tea will make you to shed off weight and and lower lipid levels: Zingerone, a natural compound found in cooked ginger, decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 31/May/2019, 3.12 pm

Amino acid-based therapy for Myocardial Infarction:  L-Histidine, an essential amino acid and  precursor for Histamine, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up regulation of PNUTS, 31/May/2019, 2.49 pm
May 31, 2019
Chronic isolation stress promotes the development of type II diabetes mellitus and cardiovascular dysfunction: Chronic isolation stress decreases the expression of IGF1R, INSR, and IRS2, and inhibits insulin-sensitized state, via down-regulation of  its target gene Lin28, 1/June/2019, 5.55 pm
June 1, 2019
Show all

The significance of the study:

Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to 100 million people in the US succumb to this disease; (3) obesity and type 2 diabetes are risk factor for the development of NAFLD;  and (4) the global economic cost spent for NAFLD is enormous, there is an urgent need to find: (i) a way to decrease cholesterol deposition in liver; (ii) a cheaper alternative to the existing expensive drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, NAFLD.


Research findings to Therapeutic opportunity:

This study suggests that Ginger-derived compound Zingerone may aid in lowering cholesterol and triglyceride levels, and to treat Non-alcoholic fatty liver disease (NAFLD). Zingerone, by increasing the expression of its target gene, it may suppress the expression of HMGCR (Fig.1). Thereby, it may: (1) decrease Triglycerides, free cholesterol, and total cholesterol levels; (2) attenuate lipid deposition in the liver; and (3) inhibit progression to NAFLD (Fig. 1). Thus, a pharmaceutical formulations encompassing Zingerone or its analogs, either alone or in combination with other drugs, may be used to treat NAFLD (Fig.2).

Figure 1. Mechanistic insights into how Zingerone decreases the expression of HMGCR, lowers cholesterol levels, decreases triglyceride levels, and NAFLD

Figure 2.  Ginger-derived compound Zingerone  functions as a cholesterol-lowering agent. Zingerone  lowers cholesterol and triglyceride levels and attenuates NAFLD, through down-regulation of HMGCR

 


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Zingerone decrease the expression of HMGCR and prevent NAFLD?

Amount: $750#

# Research cooperation

For purchase and payment details, you may reach us at info@genomediscovery.org


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., Drinking ginger tea will make you to shed off weight and lower lipid levels: Zingerone, a natural compound found in cooked ginger, decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 31/May/2019, 3.12 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite us, kindly drop us a line at info@genomediscovery.org

Comments are closed.