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What they say:

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 37.205 ),  by Prof. Dominic J. Withers, Dr. Selman C and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Essential oil-derived compound may extend the lifespan of humans: Carvacrol-based Lifespan extension therapy: Carvacrol, found in the present in the essential of oregano, monarda didyma, p. amboinicus and others,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes


From research findings to Therapeutic Opportunity: 

This study suggests, for the first time, that essential oils-derived compound Carvacrol may extend lifespan. 

 Carvacrol, by regulating the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity(fig. 1).

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Figure 1. Mechanistic insights into how  Carvacrol may extend  mammalian lifespan.  Carvacrol functions as a longevity-promoter by decreasing the expression of p70S6 Kinase and increasing the expression of other longevity-promoting genes.

Figure 2. The chemical structure of  Carvacrol.

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Thus, pharmacological formulations encompassing Carvacrol or its analogs, either alone or in combination with any of the known longevity-promoting compound(s),” may be used to extend the lifespan of an individual (fig. 2).

 


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic Information: How Carvacrol  decreases the expression of p70 S6 Kinase and promotes mammalian life span

# Research cooperation

Amount: $500#

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References:

CitationBoominathan, L., Essential oil-derived compound may extend the lifespan of humans: Carvacrol-based Lifespan extension therapy: Carvacrol, found in the present in the essential of oregano, monarda didyma, p. amboinicus and others,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 22/May/2019, 12.56 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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