Have copious amount of deoxy sugar L-Rhamnose, not sucrose (table sugar), and stop worrying about lipid levels: L-Rhamnose (6-deoxy-L-Mannose) decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 14/May/2019, 9.51 am

Probiotic-based chemotherapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing a pharmacological formulation encompassing Metformin, Navitoclax/ABT-263, & Dasatinib (MND) and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as  E-cadherin, SMAD7, APAF1, p53, and TA-p73/p63, inhibits immune-inhibitory receptors/molecules, targets cancer stem cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 14/April/2019, 8.29 am
May 14, 2019
Natural sugar-based therapy targeting cancer stem cells and immune-inhibitory receptors in advanced metastatic cancers: A pharmaceutical mixture encompassing a pharmacological formulation encompassing Xylobiose (a disaccharide of xylose, with a  a beta-1,4-bond), and probiotic Lactobacillus rhamnosus increases the expression of tumor suppressor genes, such as  HNF4α, CDK2AP1, E-cadherin, p53, and TA-p73/p63, stalls cell cycle progression, inhibits immune-inhibitory receptors/molecules, suppresses cancer stem cell proliferation, inhibits migration, invasion and metastasis of cancer cells, confers protection against chemoresistance and prolongs survival, via up-regulation of its target gene, 14/May/2019, 10.40 am
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The significance of the study:

Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to 100 million people in the US succumb to this disease; (3) obesity and type 2 diabetes are risk factor for the development of NAFLD;  and (4) the global economic cost spent for NAFLD is enormous, there is an urgent need to find: (i) a way to decrease cholesterol deposition in liver; (ii) a cheaper alternative to the existing expensive drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, NAFLD.


Research findings to Therapeutic opportunity:

This study suggests a natural sugar-based therapy for lowering cholesterol and triglyceride levels, and to treat Non-alcoholic fatty liver disease (NAFLD). 

L-Rhamnose, by increasing the expression of its target gene, it may suppress the expression of HMGCR (Fig.1). Thereby, it may: (1) decrease Triglycerides, free cholesterol, and total cholesterol levels; (2) attenuate lipid deposition in the liver; and (3) inhibit progression to NAFLD (Fig. 1). Thus, a pharmaceutical formulations encompassing L-Rhamnose or its analogs, either alone or in combination with other drugs, may be used to treat NAFLD (Fig.2). Given its non-toxic nature compared to other drugs in the market, it may be an agent of choice to bring down lipid levels and  to treat NAFLD.

Figure 1. Mechanistic insights into how L-Rhamnose decreases the expression of HMGCR, lowers cholesterol levels, decreases triglyceride levels, and NAFLD

Figure 2.  L-Rhamnose  functions as a cholesterol-lowering agent. L-Rhamnose lowers cholesterol and triglyceride levels and attenuates NAFLD, through down-regulation of HMGCR

 


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does L-Rhamnose decrease the expression of HMGCR ?

Amount: $750#

# Research cooperation

For purchase and payment details, you may reach us at info@genomediscovery.org


References:

Web: http://genomediscovery.org or http://newbioideas.com  (6-deoxy-Lmannose).

Citation: Boominathan, L., Have copious amount of deoxy sugar L-Rhamnose, not sucrose (table sugar), and stop worrying about lipid levels: L-Rhamnose (6-deoxy-L-Mannose) decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via up-regulation of its target gene, 14/May/2019, 9.51 am, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite us, kindly drop us a line at info@genomediscovery.org

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