Mechanistic insights into how R-Phenibut attenuates neuropathic pain: R-Phenibut (brand name: Anvifen, Fenibut, Noofen, others), used to treat anxiety, insomnia and others, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 26/May/2019, 11.14  pm

Mechanistic insights into how Anandamide attenuates neuropathic pain: Anandamide, isolated from Cannabis, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 24/May/2019, 11.12  pm
May 24, 2019
Mindfulness meditation-based PD-1 pathway activation for Pain therapy: Mindfulness meditation increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 26/May/2019, 11.35 pm
May 26, 2019
Show all

Genome-2-Bio-Medicine Discovery center founder’s father’s (teacher) death anniversary day-26th  May

*********

On the eve of Genome-2-Bio-Medicine Discovery center founder’s father’s (teacher) death anniversary day, we wish to inform you that the Bio-Medical ideas posted today (26/May/2019) will be available to the use of Scientists/Professors/Physicians/Researchers/Post-doctoral fellows/Teachers/faculty members for free. So, there will be no terms and conditions for the ideas posted today (26/May/2019). Each idea posted will be served first come, first served basis. Write to us at info@genomediscovery.org for more details. 

Dr L Boominathan PhD

Founder President & CSO, GBMD.

_________________________________________________________________________________________________

 

Introduction:What they say:

A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China; and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, US shows that “PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1.” This study was published, in the 22 May 2017 issue of Nature Neuroscience (one of the best journals in Neurobiology with an impact factor of 16.724+), by Prof Ji RR, Chen G and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic insights into how R-Phenibut  attenuates neuropathic pain: R-Phenibut (brand name: Anvifen, Fenibut, Noofen, others), used to treat anxiety, insomnia and others, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene


What is known?

It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year. However, the work published recently, which is described below, may highlight the caveat in such an approach, as blocking PD-L1 may promote spontaneous pain and allodynia in cancer-bearing mice.

Prof. Ji has shown recently that: (1) Programmed cell death ligand-1 (PD-L1), produced by melanoma and normal neural tissues, inhibits acute and chronic pain; (2) injection of PD-L1 alleviates pain, and thereby functions as an analgesic agent; (3) Neutralization of PD-L1 or Block of PD1 promotes mechanical allodynia (hypersensitivity to pain); (4) PD1 null mice suffers from thermal and mechanical hypersensitivity; (5) PD-L1 promotes phosphorylation of SHP-1 and inhibits Sodium channels via PD-1 activation; and (6) PD-L1 inhibits nociceptive neuron excitability in dorsal root ganglion and thereby functions as a neuromodulator, suggesting that increasing the expression or the level of PD-L1/PD1 may alleviate pain and thermal and mechanical hypersensitivity.


From research findings to therapeutic opportunity:

R-Phenibut has been shown to treat neuropathic pain and others.   However, the mechanism of action remains far from clear.

The study presented here suggests, for the first time, that R-Phenibut, by increasing the expression of its target genes, it may increase PD-L1 levels (figs. 1-2). Thereby, it may: (a) inhibit acute and chronic pain; (b) alleviate thermal and mechanical hypersensitivity; (c) activate signal transduction cascade downstream of PD-1 receptor; (c) phosphorylate SHP-1; (d) inhibit sodium channels and nociceptive neuron excitability.

Figure 1.Mechanistic insights into how R-Phenibut inhibits acute and chronic pain. R-Phenibut enhances PD-L1 levels, suppresses thermal and mechanical hypersensitivity, phosphorylates SHP-1, inhibits activation of sodium channels, and alleviates nociceptive neuron excitability

Figure 2. R-Phenibut  functions as an analgesic agent through induction of PD-L1

Thus, pharmacological formulations encompassing ” R-Phenibut or its analogs, either alone in combination with other drugs,” may be used to attenuate short-term and long-term pain.


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $500#

Undisclosed mechanistic information: How R-Phenibut  increases the expression of PD-L1 and attenuates pain.

# Research cooperation


References:

Citation: Boominathan, L., Mechanistic insights into how R-Phenibut  attenuates neuropathic pain: R-Phenibut (brand name: Anvifen, Fenibut, Noofen, others), used to treat anxiety, insomnia and others, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 26/May/2019, 11.14  pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.