What they say?
A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Treating cancers with longevity-promoting agents: Anticancer agent Bexarotene functions as a longevity-promoting agent: Bexarotene inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, via up regulation of its target gene
Research findings to Therapeutic opportunity:
This study provides mechanistic insights into how anticancer drug Bexarotene may function as a longevity-promoting agent. Bexarotene, by increasing the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).
Thus, pharmacological formulations encompassing ” Bexarotene or its analogs, either alone or in combination with any of the known longevity-promoting compound(s),“ may be used to extend the lifespan of an individual (fig. 1). Together, this study suggests, for the first time, that consuming neuropeptide Y (NPY) activators may extend health and life span.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic Information: How does Bexarotenedecrease the expression of p70 S6 Kinase?
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Citation: Boominathan, L., Treating cancers with longevity-promoting agents: Anticancer agent Bexarotene functions as a longevity-promoting agent: Bexarotene inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, via up regulation of its target gene, 8/May/2019, 7.13 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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