Treating cancers with longevity-promoting agents: Anticancer agent Bexarotene functions as a longevity-promoting agent: Bexarotene inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, via up regulation of its target gene, 8/May/2019, 7.13 am

Canagliflozin-based therapy for Cardiac repair and myocardial infarction: Canagliflozin (trade name: Invokana, Sulisent, Prominad, others), a sodium-glucose cotransporter 2 inhibitor used in the treatment of TIIDM, increases Agrin expression, activates Yap and ERK-mediated signaling,  replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up-regulation of its target gene, 8/May/2019,  6.59 am
May 8, 2019
Autologous blood transfusion as a curative therapy for chronic pain: Autologous blood transfusion increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 8/May/2019, 7.31 am
May 8, 2019
Show all

What they say? 

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Treating cancers with longevity-promoting agents: Anticancer agent Bexarotene functions as a longevity-promoting agent: Bexarotene  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, via up regulation of its target gene


Research findings to Therapeutic opportunity: 

This study provides mechanistic insights into how anticancer drug Bexarotene may function as a longevity-promoting agent. Bexarotene, by  increasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).   

Figure 1. Mechanistic insight into how Bexarotene may extend lifespan. Bexarotene inhibits p70 S6 kInase expression and increases the expression of other longevity- promoting genes

Figure 2. The chemical structure of Bexarotene.  Bexarotene functions as a longevity promoting agent through down regulation of p70S6 kinase

[easy_payment currency=”USD”]

Thus, pharmacological formulations encompassing ” Bexarotene or its analogs,  either alone or in combination with any of the known longevity-promoting compound(s), may be used to extend the lifespan of an individual (fig. 1). Together, this study suggests, for the first time, that consuming neuropeptide Y (NPY) activators may extend health and life span. 


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic Information: How does Bexarotenedecrease the expression of p70 S6 Kinase?

# Research cooperation

Amount: $500#

For purchase and payment information, you may reach us at info@genomediscovery.org


References:

CitationBoominathan, L., Treating cancers with longevity-promoting agents: Anticancer agent Bexarotene functions as a longevity-promoting agent: Bexarotene inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, via up regulation of its target gene, 8/May/2019, 7.13 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.