Chronic isolation stress promotes the development of type II diabetes mellitus and cardiovascular dysfunction: Chronic isolation stress decreases the expression of IGF1R, INSR, and IRS2, and inhibits insulin-sensitized state, via down-regulation of  its target gene Lin28, 1/June/2019, 5.55 pm

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IntroductionWhat they say:  

A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published, in the 30 September  2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of 28.71] by Prof George Q Daley, the present Dean of the Harvard Medical School, Zhu H, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Chronic isolation stress promotes the development of type II diabetes mellitus and cardiovascular dysfunction: Chronic isolation stress decreases the expression of IGF1R, INSR, and IRS2, and inhibits insulin-sensitized state, via down-regulation of  its target gene Lin28

 


From significance of the study to Public health relevance: 

Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) Diabetes is going to be one of the top 10 causes of death by 2030; (3) the life-long painful injection/drug treatment is required to treat DM; (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells and cardiomyocytes that were lost in DM (Diabetes Mellitus) and MI (Myocardial infarction), respectively; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.


What is known?

Prof. George Q and his research team members had shown earlier that loss of Lin28 in muscles promotes insulin resistance and glucose intolerance. 


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, that chronic isolation stress, by decreasing the expression of its target gene, it may (1) decrease the expression of IGF1R, INSR, and IRS2; (2) inhibit tissue repair; (3) attenuate regeneration of pancreatic β-cells; (3) decrease regenerative capacity; (4) decrease insulin sensitivity; and (5) promote the development of type II diabetes mellitus (TIIDM) and dilated cardiomyopathy (DCM) (Fig.1).

Figure 1. Mechanistic insights into how chronic isolation stress promotes the development of type II diabetes and myocardial dysfunction. Chronic isolation stress promotes insulin resistance and  cardiovascular dysfunction via don-regulation of reprogramming protein Lin-28

Figure 2. While Lin-28 inducers may function as antidiabetic agents, chronic isolation stress may inhibit Lin-28 expression and result in the development of type II diabetes.

Given the deleterious health consequences of chronic isolation stress, it needs to be avoided to protect against TIIDM and DCM.


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $ 500#

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does chronic isolation stress promote insulin resistance?

# Research cooperation


References

Web: http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan L, Chronic isolation stress promotes the development of type II diabetes mellitus and cardiovascular dysfunction: Chronic isolation stress decreases the expression of IGF1R, INSR, and IRS2, and inhibits insulin-sensitized state, via down-regulation of  its target gene Lin28, 1/June/2019, 5.55 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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