Solving a fifty plus year puzzle as to how labor pain relief medication Fentanyl functions as a pain reliever: Mechanistic insights into how Fentanyl functions as an analgesic agent: Fentanyl (trade name: Actiq, Duragesic, Fentora, Sublimaze and others), used to treat moderate to severe pain during labor and delivery, in post-operative pain management, in chronic cancer pain management and in others, increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 31/July/2019, 8.09 pm
Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China; and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, US shows that “PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron […]
Probiotics as biological drugs: Repurposing the Probiotic Verrucomicrobia Akkermansia Muciniphila into a longevity/healthspan-promoting bio-drug: Probiotic Verrucomicrobia Akkermansia Muciniphila inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 30/July/2019, 8.39 am
Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia shows that “A conserved NAD+ binding pocket that regulates protein-protein […]
Solving a seventy plus year puzzle as to how labor pain relief medication Pethidine functions as a pain reliever: Mechanistic insights into how Pethidine functions as an analgesic agent: Pethidine (trade name: Meperidine/Demerol), used to decrease feeling in a specific area of the body, in post-operative pain management, in the treatment of lower back pain and in others, increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 29/July/2019, 2.48 pm
Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China; and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, US shows that “PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron […]
Solving a sixty plus year puzzle as to how Bupivacaine functions as a pain reliever: Mechanistic insights into how Bupivacaine functions as a local anesthetic agent: Bupivacaine (trade name: Marcaine, Sensorcaine, Vivacaine, others ), used to decrease feeling in a specific area of the body, in post-operative pain management, in the treatment of lower back pain and in others, increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 24/July/2019, 6.34 am
Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China; and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, US shows that “PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron […]
Probiotic-based therapy for aging-associated diseases and Lifespan extension: A therapeutic mix encompassing Probiotic Bifidobacterium LKM512 and Arginine inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 23/July/2019, 8.03 am
Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia shows that “A conserved NAD+ binding pocket that regulates protein-protein […]
Solving a sixty-year old puzzle as to how Amitriptyline functions as a pain reliever: Mechanistic insights into how Amitriptyline functions as a pain medication: Amitriptyline (trade name: Elatrol, Elatrolet, Elavil, Endep, Fiorda, Laroxyl, Latilin, Levate and others), used in the treatment for major depressive order, and anxiety disorders, prevention of migraines, fibromyalgia, postherpetic neuralgia, and insomnia, increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 12/July/2019, 11.29 pm
Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China; and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, US shows that “PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron […]
