July

July 31, 2019

Solving a fifty plus year puzzle as to how labor pain relief medication Fentanyl functions as a pain reliever: Mechanistic insights into how Fentanyl  functions as an analgesic agent: Fentanyl (trade name: Actiq, Duragesic, Fentora, Sublimaze and others), used to treat moderate to severe pain during labor and delivery, in post-operative pain management, in chronic cancer pain management and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 31/July/2019, 8.09 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
July 30, 2019

Probiotics as biological drugs: Repurposing the Probiotic Verrucomicrobia Akkermansia Muciniphila into a longevity/healthspan-promoting bio-drug:  Probiotic Verrucomicrobia Akkermansia Muciniphila inhibits the interaction of DBC1 with PARP1, increases the PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 30/July/2019, 8.39 am

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
July 29, 2019

Solving a seventy plus year puzzle as to how labor pain relief medication Pethidine functions as a pain reliever: Mechanistic insights into how Pethidine  functions as an analgesic agent: Pethidine (trade name: Meperidine/Demerol), used to decrease feeling in a specific area of the body, in post-operative pain management, in the treatment of lower back pain and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 29/July/2019, 2.48 pm

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
July 24, 2019

Solving a sixty plus year puzzle as to how Bupivacaine functions as a pain reliever: Mechanistic insights into how Bupivacaine functions as a local anesthetic agent: Bupivacaine  (trade name: Marcaine, Sensorcaine, Vivacaine, others ), used to decrease feeling in a specific area of the body, in post-operative pain management, in the treatment of lower back pain and in others,  increases the expression of PD-L1, decreases the expression of Cox-2, TRPV1, and CGPR, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 24/July/2019, 6.34 am

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]