Where the peel is more valuable than the fruit (pulp): Citrus peel is enriched with longevity-promoting compounds than pulp: Citrus peel-based Lifespan extension therapy:  A pharmaceutical mixture encompassing Hesperidin, Tangeretin & Nobiletin (HTN), derived from citrus peel,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 5/July/2019, 10.17 pm

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What they say:

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 37.205 ),  by Prof. Dominic J. Withers, Dr. Selman C, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that:Where the peel is more valuable than the fruit (pulp): Citrus peel is enriched with longevity-promoting compounds than pulp: Citrus peel-based Lifespan extension therapy:  A pharmaceutical mixture encompassing Hesperidin, Tangeretin & Nobiletin (HTN), derived from citrus peel,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 5/July/2019, 10.17 pm


From research findings to Therapeutic Opportunity: 

This study suggests, for the first time, with detailed mechanistic insights, that Citrus peels, and its components, such as  Hesperidin, Tangeretin & Nobiletin (HTN), may extend the lifespan of humans.  HTN, by regulating the expression of its target gene, it may suppress the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase). Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity(fig. 1).

Figure 1. Mechanistic insights into how a pharmaceutical mixture encompassing Hesperidin, Tangeretin & Nobiletin (HTN)  may extend  mammalian lifespan.  HTN functions as a longevity-promoter by decreasing the expression of p70S6 Kinase and increasing the expression of a number of longevity-promoting genes.

Figure 2. The chemical structures of  Hesperidin, Tangeretin & Nobiletin (HTN). HTN, derived from Citrus peels, extends lifespan through down regulation of p70 S6 kinase.

Figure 3. While genetic ablation of p70S6 Kinase extends lifespan, a pharmaceutic mixture encompassing Hesperidin, Tangeretin & Nobiletin (HTN), by decreasing the expression of p70S6 Kinase, it increases insulin sensitivity, promotes resistance to bone, immune, and motor dysfunction, and extends lifespan.

 

Thus, a pharmacological formulation encompassing “Hesperidin, Tangeretin & Nobiletin (HTN) or their analogs, either alone or in combination with any of the known longevity-promoting compound(s),” may be used to extend the lifespan of an individual (fig. 2).

Given the mechanistic basis as to how Hesperidin, Tangeretin & Nobiletin (HTN), derived from citrus peels, can extend lifespan of humans, its consumption can be increased. 

Together, this study provide mechanistic insights into how to go about living longer by consuming citrus peels. 


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic Information: How a pharmaceutical mixture encompassing Hesperidin, Tangeretin & Nobiletin (HTN) decreases the expression of p70 S6 Kinase?

# Research cooperation

Amount: $500#

For purchase and payment information, you may reach us at info@genomediscovery.org


References:

CitationBoominathan, L., Where the peel is more valuable than the fruit (pulp): Citrus peel is enriched with longevity-promoting compounds than pulp: Citrus peel-based Lifespan extension therapy:  A pharmaceutical mixture encompassing Hesperidin, Tangeretin & Nobiletin (HTN), derived from citrus peel,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 5/July/2019, 10.17 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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