Live longer by consuming polyamine-rich foods: Spermine-based Lifespan extension therapy: Spermine, one of the polyamines, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 1/August/2019, 11.29 pm
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What they say:
A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 37.205 ), by Prof. Dominic J. Withers, Dr. Selman C, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Live longer by consuming polyamine-rich foods: Spermine-based Lifespan extension therapy: Spermine, one of the polyamines, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes
From research findings to Therapeutic Opportunity:
This study suggests, for the first time, with detailed mechanistic insights, Polyamine, such as Spermine may extend lifespan of humans. Spermine, by regulating the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression and other genes (fig 1). Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (figs. 2-5).
Figure 1. Mechanistic insights into how Polyamine Spermine extends mammalian lifespan. Spermine functions as a longevity-promoter by decreasing the expression of p70S6 Kinase and increasing the expression of a number of longevity-promoting genes.
Figure 2. Polyamine Spermine, by decreasing the expression of p70S6 Kinase, it increases insulin sensitivity, promotes resistance to bone, immune, and motor dysfunction, and extends lifespan.
Figure 3. Foods enriched with Spermine. Spermine functions as a longevity promoter through down regulation of p70 S6 kinase and other genes.
Figure 4. Centenarians (those how live 100 years and beyond) have higher levels of polyamine spermine in their blood compared with octogenarians (ordinary ageing).
Figure 5. While genetic ablation of p70S6 Kinase has been shown to extend lifespan, this study suggests that polyamine spermine increases insulin sensitivity, promotes resistance to bone, immune, and motor dysfunction, and extends lifespan.
Thus, pharmacological formulations encompassing “Polyamine spermine or its analogs, either alone or in combination with any of the known longevity-promoting compound(s),” may be used to extend the lifespan of an individual (fig. 2).
Given the mechanistic basis as to how polyamine Spermine can extend lifespan of humans, its consumption can be increased.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic Information: How Spermine decreases the expression of p70 S6 Kinase and promotes mammalian life span
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References:
Citation: Boominathan, L., Live longer by consuming polyamine-rich foods: Spermine-based Lifespan extension therapy: Spermine, one of the polyamines, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan by regulating the expression of its target genes, 1/August/2019, 11.29 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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