Sunshine vitamin functions as a broad-spectrum anti-infective agent: Calcitriol/Cholecalciferol (1,25-dihydroxyvitamin D3)/Tacalcitol inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 4/September/2019,  10.19 pm

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Introduction: What they say:

A study from the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Charlestown, MA 02129, USA shows that “The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus.” This study was published, in the 24 December 2009 issue of the journal “Cell” (the number 1 research journal in General Biology with an impact factor of 33),  by the 2015 Laskar award winner (often referred to as “America’s Nobels”) Prof. Stephen Elledge, Abraham Brass and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Sunshine vitamin functions as a broad-spectrum anti-infective agent:   Calcitriol/Cholecalciferol (1,25-dihydroxyvitamin D3)/Tacalcitol inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15


What is known?

Prof. Stephen Elledge research team has showed that interferon-inducible transmembrane proteins IFITM1, 2, and 3 inhibit  influenza A H1N1 virus, West Nile virus, and dengue virus replication, suggesting that increasing the expression of IFITM3 may confer resistance against these viruses. Other studies suggest that IFITM3 may also protect against Ebola virus, hepatitis C virus, yellow fever virus and SARS coronavirus etc.


From research findings to therapeutic opportunity: 

This study suggests, for the first time, that Calcitriol/Cholecalciferol (1,25-dihydroxyvitamin D3)/Tacalcitol(1,24-dihydroxyvitamin D3)/Vitamin D3, by increasing the expression of its target genes, it may increase the expression of interferon-inducible transmembrane protein IFITM3, Interferon-stimulated gene-15, Mx2 and antimicrobial peptides. Thereby, it may: (1) inhibit the replication of  Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses; (2) confer resistance against  infection caused by Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses; and (3) promote innate immunity (Figure 1)

Figure 1. Mechanistic insight into how Calcitriol/Cholecalciferol (1,25-dihydroxyvitamin D3)/Tacalcitol (1,24-dihydroxyvitamin D3) inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial , Sindbis, and SFV viruses production through induction of its target genes, such as antiviral Proteins IFITM3, Interferon-stimulated gene 15 (ISG15), & Mx2

Figure 2. Calcitriol/Cholecalciferol/Tacalcitol functions as a broad-spectrum anti-infective agent through induction of ISG15, IFITM3, MX2 and others.

Figure 3. While it had been shown that increased expression of IFITM3 and others inhibits the replication of influenza A H1N1 virus, West Nile virus, and dengue virus and others, the study presented here suggests, for the first time, that, Calcitriol/Cholecalciferol/Tacalcitol increases the expression of ISG15, IFITM3, and MX2 . And, thereby, it functions as a broad-spectrum anti-infective agent.

Thus, pharmacological formulations encompassing “Calcitriol/Cholecalciferol (1,25-dihydroxyvitamin D3)/Tacalcitol or its analogues, either alone or in combination with other drugs” may be used to prevent/treat infections caused by Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses (Figures 2-3).


Details of the research findings: 

Idea formulated by Dr L Boominathan PhD

Undisclosed information: How  Calcitriol/Cholecalciferol(1,25-dihydroxyvitamin D3)/Tacalcitol increases the expression of antiviral Protein IFITM3, Interferon-stimulated gene 15, & Mx2

Amount: $ 1, 500#

# Research cooperation

For more details on payment, you may reach us at admin@genomediscovery.org


References: 

CitationBoominathan L,   Sunshine vitamin functions as a broad-spectrum anti-infective agent:   Calcitriol/Cholecalciferol (1,25-dihydroxyvitamin D3)/Tacalcitol inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the Antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 4/September/2019,  10.19 pm

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