A cup of Chamomile tea everyday may extend your lifespan:  Apigenin-based anti-ageing and Lifespan extension therapy:  Apigenin (4′,5,7-trihydroxyflavone), the main constituent of Chamomile tea and others, increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels, increases telomerase levels, and enhances lifespan, via up regulation of its target gene, 20/December/2019, 12.47 pm

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Introduction: What they say 

A study from Institute for Cell Biology, University of Bonn, Ulrich-Haberland Str.  Bonn, Germany; and Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann Str. Cologne, Germany shows that “The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.” This research paper was published, in the 20 April 2017 issue of the journal “Cell” [One of the best research journals in Biology with an I.F of 28 plus], by Prof. Hoppe TTawo R and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A cup of Chamomile tea everyday may extend your lifespan:  Apigenin-based anti-ageing and Lifespan extension therapy:  Apigenin (4′,5,7-trihydroxyflavone), the main constituent of Chamomile tea and others, increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels, increases telomerase levels, and enhances lifespan, via up regulation of its target gene


What is known?

Prof. Hoppe T’s research team has recently shown that knocking down CHIP gene in mice results in a) increased protein levels of insulin receptor (INSR); and b) reduced lifespan. Further, they have shown that CHIP targets INSR for mono ubiquitylation and degradation, while its ability to degrade INSR is compromised upon proteotoxic stress and during ageing, as CHIP is directed toward disposal of misfolded proteins, rather than degrade the INSR.


From Research findings to Therapeutic opportunity:

This study suggests a natural product-based anti-ageing/life-extension therapy.

Apigenin (4′,5,7-trihydroxyflavone), also known as Apigenine, Chamomile, Apigenol, Versulin, and others, can be derived from a number of natural resources, including parsley, celery, celeriac and chamomile, has been shown to be associated with anti-ageing/senescent effects in mice. However, the mechanistic basis of its anti-ageing effect is largely unknown up until now.

Interestingly, long-lived Mexican-American american women (over 65 years) consume large amount of chamomile tea.  Chamomile tea is the national drink of ItalyInterestingly, Apigenin makes up to 68% of total flavanoids in chamomile tea.  And, those Mexican-American american elderly women (over 65 years and above), who consume chamomile tea,  are protected from mortality, from all causes, by 28% (Howrey BT et al., Gerontologist, 56 (6), 1146-1152 Dec 2016). However, the mechanistic basis of its therapeutic benefit in life-extension is unknown up until now.

This study suggests, for the first time, that Apigenin (4′,5,7-trihydroxyflavone), by increasing the expression of its target gene, it could increase the levels of CHIP (carboxy terminus of Hsc70 interacting protein). Thereby, it may: (1) increase CHIP-assisted proteolysis; (2) increase mono ubiquitylation and degradation of INSR (Insulin receptor); (3) inhibit the insulin and IGF1 signaling pathway; (4) inhibit accumulation of misfolded proteins; (5) increase telomerase levels; (6) prevent dementia; (7) attenuate muscle weakness; and (8) enhance longevity (Fig.1).

Figure 1. Mechanistic insights into how Apigenin (4′,5,7-trihydroxyflavone) induces CHIP expression and extends lifespan.  Apigenin enhances folding of proteins, prevents protein aggregation and extends life span through induction of CHIP and telomerase levels; and degradation of INSR (Insulin receptor).

Figure 2. The chemical structure of  Apigenin (4′,5,7-trihydroxyflavone). Apigenin (4′,5,7-trihydroxyflavone), the main constituent of Chamomile (68% of total flavonoids) and others, can promote life extension through induction of CHIP.

Figure 2. Mechanistic insights into how consumption of Chamomile tea can extend lifespan. Apigenein, the main constituent of Chamomile tea, can promote life extension through induction of CHIP and down regulation of INSR (insulin receptor).

Figure 3. While it has been shown that genetic deletion of the Ubiquitin Ligase CHIP1 reduces longevity in worms and others, this study suggests, for the first time, that  Apigenin (4′,5,7-trihydroxyflavone)  could extend lifespan through induction of CHIP1 and degradation of INSR.

Thus, pharmacological formulations encompassingApigenin (4′,5,7-trihydroxyflavone) or its analogues, either alone or in combination with other compounds,may be used to suppress age-associated overall physiological decline and improve health/life span (Figs. 2-4).

Given the mechanistic basis of Apigenin (4′,5,7-trihydroxyflavone), in life-span extension in humans, especially in women, the consumption of Apigenin (4′,5,7-trihydroxyflavone)-enriched beverages, such as Chamomile tea and others, can be increased.


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How Apigenin (4′,5,7-trihydroxyflavone) decreases the levels of INSR and extends longevity

Amount:$ 1, 500#

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., A cup of Chamomile tea everyday may extend your lifespan:  Apigenin-based anti-ageing and Lifespan extension therapy:  Apigenin (4′,5,7-trihydroxyflavone), the main constituent of Chamomile tea and others, increases CHIP levels, increases monoubiquitylation of insulin receptor (INSR), decreases INSR protein levels, increases telomerase levels, and enhances lifespan, via up regulation of its target gene, 20/December/2019, 12.47 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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