What they say: Introduction:
A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that “Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan.” This study was published, in the 12 May 2014 issue of the journal “EMBO”, by Prof Sinclair PhD, North BJ, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic insights into Okinawan longevity diet: Consuming ample amounts of Sweet potatoes will extend your lifespan: Sweet potato-derived compounds function as longevity promoters: ß-carotene, derived from sweet potatoes, may increase insulin sensitivity, slow down cardiac aging, increase regeneration of tissues, and increase lifespan, via up-regulation of BubR1 and others genes
From research findings to Therapeutic Opportunity:
Although 70% of Okinawan longevity diet, consumed by long-lived people from an island in Japan, Okinawa, consists only of Sweet potato, its mechanism of action remains elusive. Besides, people from Bapan, a region from China, who live past hundred years in great health, consume nearly half-a-kilo of a sweet potato every day. However, how increased consumption of sweet potato may aid in extending the lifespan, mechanistically, is not clear up until now.
This study suggests, for the first time, that Sweet potato–derived compounds function as longevity-promoters. ß-carotene, by increasing the expression of its target gene, it could: (a) increase the expression of BuBR1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase); (b) decrease the expression of p70 S6 Kinase, and (c) regulate the expression of a number of longevity-promoting molecules (fig. 1). Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue & cell rejuvenation; and (7) prolong median lifespan.
Thus, a pharmaceutical mixture encompassing ß-carotene, either alone or in combination with other drugs or compounds,“ may be used to extend the lifespan of an individual (fig.5). Given the mechanistic significance of consumption of longevity medicine sweet potato and its component ß-carotene, its consumption can be increased throughout the world.
Details on the research findings:
Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.
Amount: $ 1, 500#
Undisclosed mechanistic information: How ß-carotene increase the expression of BubR1?
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
# Research cooperation
Citation: Boominathan, L., Mechanistic insights into Okinawan longevity diet: Consuming ample amounts of Sweet potatoes will extend your lifespan: Sweet potato-derived compounds function as longevity promoters: ß-carotene, derived from sweet potatoes, may increase insulin sensitivity, slow down cardiac aging, increase regeneration of tissues, and increase lifespan, via up-regulation of BubR1 and others genes, 11/December/2019, 6.58 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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