Lifespan extension therapy comes of age: Fluval [Fluvastatin (10 mg) and Valsartan (20 mg)] aids in Lifespan extension: A pharmaceutical mixture encompassing Fluvastatin (10 mg) and Valsartan (20 mg) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, increases adult stem cell proliferation, alleviates ageing feature and extends lifespan, via upregulation of its target genes ATG5 (Autophagy-related 5) and telomerase, 29/December/2019, 11.59 pm

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Introduction: What they say

A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published, in the online journal “Nature Communications”,  by Prof. Jung YK, Pyo Jo, and others.

Earlier, Prof. Yoshinori Ohsumi, from Institute of Innovative Research, Tokyo Institute of Technology, who won the Nobel prize in Physiology or Medicine, in 2016, discovered the mechanisms of Autophagy, including the role of ATG5 in the regulation of autophagy.


What we say: 

On the foundation of these interesting findings, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Lifespan extension therapy comes of age: Fluval [Fluvastatin (10 mg) and Valsartan (20 mg)] aids in Lifespan extension: A pharmaceutical mixture encompassing Fluvastatin (10 mg) and Valsartan (20 mg) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, increases adult stem cell proliferation, alleviates ageing feature and extends lifespan, via upregulation of its target genes ATG5 (Autophagy-related 5) and telomerase, 29/December/2019, 11.59 pm


From research findings to therapeutic opportunity: 

This study provides, for the first time, mechanistic insights into how a pharmaceutical mixture encompassing Fluvastatin (10 mg) and Valsartan (20 mg) could promote lifespan extension.

A pharmaceutical mixture encompassing Fluvastatin (10 mg) and Valsartan (20 mg), by promoting the expression of its target genes, it may increase the expression of ATG5 (Autophagy-related 5) and Telomerase. Thereby, it may: (1) enhance autophagy, (2) promote leanness; (3) increase insulin sensitivity; (4) improve motor function;  (5) increase regeneration of adult stem cells; and (6) prevent premature ageing; and alleviate aging features (Fig.1). Thus, a pharmaceutical mixture encompassing “Fluvastatin (10 mg) and Valsartan (20 mg) or their analogs, either alone or in combination with other longevity-promoting drugs, or any combination of statin and sartan class of drugs, may be used to extend the lifespan of an individual (Fig.1).

Figure1. Mechanistic insights into how a pharmaceutical mixture encompassing Fluvastatin (10 mg) and Valsartan (20 mg) provides life-span extension. Fluval, by increasing the expression of its target genes, it increases ATG5 (Autophagy-related protein-5), and telomerase expression, augments regeneration of adult stem cells, and promotes leanness, insulin sensitivity, motor function and longevity.

Figure 2.  A pharmaceutical mixture encompassing Fluvastatin (10 mg) and Valsartan (20 mg), by promoting the expression of ATG5, telomerase, and other longevity-promoting genes, promotes weight loss, insulin sensitivity, and motor function, and extends lifespan

Figure 3. A pharmaceutical mixture encompassing Fluvastatin (10 mg) and Valsartan (20 mg) extends lifespan through induction of ATG5 (Autophagy-related protein-5), telomerase, and other longevity-promoting genes

Given the mechanistic basis as to how Fluval (Fluvastatin (10 mg) and Valsartan (20 mg)) could aid in lifespan-extension, medical practitioners/geriatricians/longevity/anti-ageing researchers may consider recommending this to the needy/aged patients or putting/taking this promising finding, with a strong mechanistic basis, which matches with the established anti-ageing mechanisms revealed recently, into a clinical trial or for further experimentation.


Details of the research findings: 

Idea Proposed/Formulated by Dr L Boominathan PhD

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $1, 500#

For payment and purchase information, you may reach us at info@genomediscovery.org

# Research cooperation

Undisclosed mechanistic information: How does Fluval (Fluvastatin (10 mg) and Valsartan (20 mg))  increase the expression of ATG5 and telomerase ?


References: 

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite us, just drop us a line at info@genomediscovery.org

Citation: Boominathan, L., Lifespan extension therapy comes of age: Fluval [Fluvastatin (10 mg) and Valsartan (20 mg)] aids in Lifespan extension: A pharmaceutical mixture encompassing Fluvastatin (10 mg) and Valsartan (20 mg) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, increases adult stem cell proliferation, alleviates ageing feature and extends lifespan, via upregulation of its target genes ATG5 (Autophagy-related 5) and telomerase, 29/December/2019, 11.59 pm

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