What they say: Introduction:
A study from the Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, Bergamo, Italy shows that “Disruption of the Ang II type 1 receptor promotes longevity in mice.” This study was published, in the 9 Feb 2009 issue of the journal “Journal of Clinical Investigations”, by Prof Remuzzi G MD., PhD, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Mechanistic insights into how Okinawan longevity diet reduces blood pressure: Consuming ample amounts of Sweet potatoes will reduce blood pressure and extend lifespan: Sweet potato-derived compounds function as longevity promoters: ß-carotene, derived from sweet potatoes, decreases blood pressure and blood sugar levels, attenuates cardiac dysfunction, increases regeneration of tissues, and prolongs life span, via down regulation of angiotensin II type I receptor (AT1R)
Significance of the study:
Prof Remuzzi G’s research team had shown that disruption of angiotensin II type I receptor (AT1R) in mice: a) decreases cardiac and vascular injury; b) decreases oxidative damage; c) increases the number of mitochondria; d) increases the expression of pro-survival genes NAMPT and Sirtuin3; and e) prolongs lifespan of mice. Further, in cultured tubular epithelial cells, Angitensin II decreases Sirtuin3 expression; and this is prevented by Ang II type 1 receptors (AT1) antogonist, suggesting that AT1R inhibitors may extend lifespan.
From research findings to Therapeutic Opportunity:
Although 70% of Okinawan longevity diet, consumed by long-lived people from an island in Japan, Okinawa, consists only of Sweet potato, its significance remains elusive. Besides, people from Bapan, a region from China, who live past hundred years in great health, consume nearly half-a-kilo of a sweet potato every day. However, how increased consumption of sweet potato may aid in extending the lifespan, mechanistically, is not clear up until now.
This study suggests, for the first time, that Sweet potato–derived compounds function as longevity-promoters.
ß-carotene is derived from sweet potatoes and others. 100 grams of Sweet purple potato contains about 11.5 mgs of ß-carotene.
ß-carotene, by increasing the expression of its target gene, it could: (1) decrease angiotensin II type I receptor (AT1R) expression;(2) decrease blood pressure; (3) increase NAMPT expression; (4) increase NAD+ levels; (5) increase the expression of longevity-promoting genes, such as Sirtuins expression, including Sirtuin-3; (6) increase the number of mitochondria; (7) decrease oxidative damage; (8) attenaute vasucular injury; (9) decrease blood sugar levels; (10) inhibit pulmonary fibrosis; (11) enhance bacterial immunity; (12) slow down cardiac ageing; attenuate cardiac dysfunction; and promote repair after myocardial infarction; (13) decelerate ageing process, and delay the diseases of ageing; (14) increase telomerase expression, and promote tissue and cell rejuvenation; and (15) extend the lifespan of an individual.
Interestingly, more recently, Prof Remuzzi G’s research team had shown that polymorphisms in AGTR1/AT1R promoter, rs422858 and rs275653, are associated with extreme human longevity. Evidently, Japanese centenarians possessing rs275653 allele, not rs422858, express lower level AT1R in perepheral blood polymorphonuclear cells; and have lower blood pressure, suggesting that variations in AT1R gene can lower blood pressure and aid one live past 100.
This also explains why Japan has more number of centenarians compared to other parts of the world, as they consume excess amounts of sweet potatoes (70% of Okinawan diet consists only sweet potatoes), which contain ß-carotene, can lower level AT1R expression and blood pressure.
Thus, pharmacological formulations encompassing “ß-carotene or its analogs or its functional equivalents that share similar mechanism of action, either alone or in combination with other anti-ageing/longevity promoting compounds,“ can be used to extend the lifespan of an individual (Figures 1-5). Together, gerontologists/medical practitioners, by recommending aged patients to consume excess amounts of sweet purple potato or its constituent ß-carotene (2o mg), they can prevent ageing-associated (or, stress-associated) increased blood pressure and extend lifespan.
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does ß-carotene suppress the expression of angiotensin II type I receptor (AT1R)?
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Citation: Boominathan, L., Mechanistic insights into how Okinawan longevity diet reduces blood pressure: Consuming ample amounts of Sweet potatoes will reduce blood pressure and extend lifespan: Sweet potato-derived compounds function as longevity promoters: ß-carotene, derived from sweet potatoes, decreases blood pressure and blood sugar levels, attenuates cardiac dysfunction, increases regeneration of tissues, and prolongs life span, via down regulation of angiotensin II type I receptor (AT1R), 5/January/2019, 2.50 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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