Idea Proposed/Formulated by: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD.
From research findings to Therapeutic opportunity: This study suggests, for the first time, that Maritoclax (Marinopyrorle A), by suppressing the expression of its target gene p38-α, it can: a) promote cardiomyocyte proliferation & regeneration and function; and b) augment stress resistance against hypoxic stress.
Thus, pharmacological formulations encompassing “Maritoclax (Marinopyrorle A) or its analogues, either alone or in combination with other drugs” can be used to promote cardiomyocyte proliferation & regeneration; and protect against cardiac dysfunction.
# Research cooperation
Undisclosed information: How does Maritoclax (Marinopyrorle A) suppress the expression of p38-α?
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Citation: Boominathan, L., Marine bacteria aids in heart regeneration and promotes stress resistance: Maritoclax (Marinopyrorle A), found in Marine bacteria, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 10/January/2020, 7.01 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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