Mechanistic insights into how Okinawan longevity diet protects against cardiac dysfunction: Having turmeric tea on a daily basis will protect you against cardiac dysfunction and extend lifespan: Curcumin (Diferuloylmethane), found in turmeric, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 20/January/2020, 11.54 pm

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Idea Proposed/Formulated by: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD.

From research findings to Therapeutic opportunity: 

Okinawan longevity diet, consumed by long-lived people from an island in Japan, Okinawa, includes turmeric teaconsumed on a daily basis,  how consumption of turmeric tea on a daily basis protects against common age-related diseases, including cardiovascular dysfunction, and aids in extending the lifespan, mechanistically, is not clear up until now.

This study suggests, for the first time, that turmericderived compound Curcumin promotes heart regeneration and protects against cardiac dysfunction.

This study suggests, for the first time, that Curcumin (Diferuloylmethane), by suppressing the expression of its target gene tumor suppressor gene p38-α, it can: a) promote cardiomyocyte proliferation & regeneration and function; and b) augment stress resistance against hypoxic stress. 

Figure 1. Mechanistic insights into how Curcumin protects against cardiac dysfunction. Curcumin, by regulating the expression of its target gene, it inhibits the expression of p38alpha. Thereby, it increases NAD+ levels and promotes cardiomyocytes proliferation/surivival/regeneration.

Figure 2. Curcumin, found in in turmeric, function as a cardioprotective agent through down regulation of p38alpha and up regulation of NAD+ levels.

Figure 3. Turmeric tea function as a cardioprotective agent through down regulation of p38alpha and up regulation of NAD+ levels.

Thus, pharmacological formulations encompassing “Diferuloylmethane/Curcumin or its analogues, either alone or in combination with other drugs” can be used to promote cardiomyocyte proliferation & regeneration; and protect against cardiac dysfunction.  

# Research cooperation

Undisclosed information: How does Curcumin suppress the expression of p38-α?

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References: 

CitationBoominathan, L., Mechanistic insights into how Okinawan longevity diet protects against cardiac dysfunction: Having turmeric tea on a daily basis will protect you against cardiac dysfunction and extend lifespan: Curcumin (Diferuloylmethane), found in turmeric, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 20/January/2020, 11.54 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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