What they say:
A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March 2013 issue of of the journal Nature, by Profs. Stefanie Dimmeler (Director, Center for Molecular Medicine), Reinier A Boon and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Sauna/Waon based regenerative cardiovascular therapy: Molecular mechanistic insight into how Sauna/Waon therapy protects against and promotes functional recovery after Myocardial Infarction: Sauna(heat/thermal)/Waon therapy inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte proliferation, regeneration and survival after myocardial infarction, via up-regulation of its target gene
From Significance of the study to Public Health relevance:
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from 123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.
From Research Findings to Therapeutic Opportunity:
This study provides mechanistic insights into how Sauna(heat/thermal)/Waon therapy could protect against myocardial dysfunction.
Sauna(heat/thermal)/Waon therapy, by increasing the expression of its target genes, it could increase the expression of PNUTS [Phosphatase 1 nuclear targeting subunit (PNUTS)](fig.1). Thereby, it may: (1) inhibit DNA damage responses, (2) increase telomerase expression, (3) increase the expression of reprogramming factors; (4) inhibit telomere shortening; (4) promote cardiomyocyte survival/regeneration/proliferation; (5) decelerate aging; and (6) extend lifespan (fig 1).
Thus, by recommending aged cardiac patients to undergo Sauna(heat/thermal)/Waon therapy four times a week, one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests, for the first time, with detailed mechanistic insights that Sauna(heat/thermal)/Waon therapy can be used to protect against myocardial infarction or improve cardiac function after myocardial infarction and cardiac dysfunction (figs. 2-4).
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How does Sauna(heat/thermal) or Waon therapy increase the expression of PNUTS/Telomerase/reprogamming factors?
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Citation: Boominathan, L., Sauna/Waon based regenerative cardiovascular therapy: Molecular mechanistic insight into how Sauna/Waon therapy protects against and promotes functional recovery after Myocardial Infarction: Sauna(heat/thermal)/Waon therapy inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte proliferation, regeneration and survival after myocardial infarction, via up-regulation of its target gene, 17/January/2019, 10.45 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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