Dr L Boominathan PhD
President, Director & CSO, GBMD.
Introduction: What they say:
A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published, in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of 24.973], by Drs. Zusen Fan, Xia and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that: Mechanistic insights into how Vitamin C/Ascorbic acid enhances immunity against bacterial infections: Ascorbic acid-based immune enhancement therapy: Ascorbic acid increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 28/February/2020, 10.26 am
From Research Findings to Therapeutic Opportunity:
It is known for years that intake of Vitamin-C augments immunity. However, the mechanistic basis of which largely remains unclear.
This study suggests, for the first time, Ascorbic acid, by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in the cytoplasm; and (3) promote innate immunity against bacterial infection.
Together, pharmacological formulations encompassing “Ascorbic acid or its analog, either alone or in combination with other drugs,” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance (figs. 1 and 2).
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How does Ascorbic acid enhance innate immunity against bacterial infections?
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Citation: Boominathan, L., Mechanistic insights into how Vitamin C enhances immunity against bacterial infections: Ascorbic acid-based immune enhancement therapy: Ascorbic acid increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 28/February/2020, 10.27 am, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org
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