Mechanistic insights into how Vitamin C/Ascorbic acid enhances immunity against bacterial infections: Ascorbic acid-based immune enhancement therapy: Ascorbic acid increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 28/February/2020, 10.27 am

Repurposing the anti-hypertensive agent into an anti-malarial agent: Nifidipine, a calcium channel blocker, increases Ferroportin expression, decreases intracellular iron accumulation, inhibits cellular damage, prevents hemolysis, and inhibits malaria infection, via upregulation of its target gene, 28/February/2020, 9.39 am
February 28, 2020
Repurposing the anti-allergic drug into a cardioprotective drug: Tranilast-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients: Tranilast, an anti-allergy drug increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via up-regulation of its target gene, 1/March/2020, 5.43 pm
March 1, 2020
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National Science day special

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We wish everyone a very happy national science day. On this special occasion, we are happy to announce that Bio-Med/Pharma/Therapeutic/Clinical ideas posted today (28/February/2020) will be available to the use of Scientists/Professors/Faculties/Teachers/Physicians/Researchers for free. So, there will be no terms and conditions for the ideas posted today. Each idea posted will be served first come, first serve basis. Write to admin@genomediscovery.org for more details.

Dr L Boominathan PhD

President, Director & CSO, GBMD.

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Introduction: What they say:  

A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published, in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of  24.973], by Drs. Zusen Fan, Xia and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, the Director-cum-chief Scientist of GBMD, reports that: Mechanistic insights into how Vitamin C/Ascorbic acid enhances immunity against bacterial infections: Ascorbic acid-based immune enhancement therapy: Ascorbic acid increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 28/February/2020, 10.26 am


From Research Findings to Therapeutic Opportunity:

It is known for years that intake of Vitamin-C augments immunity. However, the mechanistic basis of which largely remains unclear.

This study suggests, for the first time, Ascorbic acid, by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in the cytoplasm; and (3) promote innate immunity against bacterial infection. 

This image has an empty alt attribute; its file name is Ascorbic-acid-promotes-innate-immunity-against-bacterial-infection-through-induction-of-reprogamming-protein-Sox2.jpg1_-770x578.jpg

Figure 1. Ascorbic acid-based immune enhancement therapy. Ascorbic acid, by increasing the expression of its target genes, it increases the expression of Sox-2 and its downstream components in the signaling pathway. And, thereby, promotes anit-bacterial immunity.

This image has an empty alt attribute; its file name is Ascorbic-acid-promotes-innate-immunity-against-bacterial-infection-through-induction-of-reprogamming-protein-Sox2-3-770x578.jpg

Figure 2. Ascorbic acid increases resistance against bacterial infection through induction of Sox2

Together, pharmacological formulations encompassing “Ascorbic acid or its analog,  either alone or in combination with other drugs,” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance (figs. 1 and 2). 


Details of the research findings

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does  Ascorbic acid enhance innate immunity against bacterial infections?

Amount: $750

# Research cooperation

For purchase and payment details, you may reach us at info@genomediscovery.org


References:

CitationBoominathan, L., Mechanistic insights into how Vitamin C enhances immunity against bacterial infections: Ascorbic acid-based immune enhancement therapy: Ascorbic acid increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 28/February/2020, 10.27 am,  Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com/

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