Mechanistic insights into how Blue zone longevity diet protects against cardiac dysfunction: Having honey on a daily basis will protect you against cardiac dysfunction and extend lifespan:Chrysin, found in propolis and honey, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 20/February/2020, 8.10 pm

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Idea Proposed/Formulated by: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD.

From research findings to Therapeutic opportunity: 

Blue zone longevity diet, consumed by long-lived people from blue zone, such as Okinawa (Japan); Sardinia (Italy); Nicoya (Costa Rica); Icaria (Greece); and Loma Linda, California(USA), includes honey, consumed on a daily basis.  However, how consumption of honey on a daily basis protects against common age-related diseases, including cardiovascular dysfunction, and thereby aids in extending the lifespan, mechanistically, is not clear up until now.

This study suggests, for the first time, that honey-derived compound chrysin promotes heart regeneration and protects against cardiac dysfunction.

Chrysin ( 5,7-Dihydroxyflavone), by suppressing the expression of its target gene tumor suppressor gene p38-α, it can: a) promote cardiomyocyte proliferation & regeneration and function; and b) augment stress resistance against hypoxic stress. 

 Figure 1. Mechanistic insights into how Chrysin protects against cardiac dysfunction. Chrysin, by regulating the expression of its target gene, it inhibits the expression of p38alpha. Thereby, it increases NAD+ levels and promotes cardiomyocytes proliferation/surivival/regeneration.
Figure 1. Mechanistic insights into how Chrysin protects against cardiac dysfunction. Chrysin, by regulating the expression of its target gene, it inhibits the expression of p38alpha. Thereby, it increases NAD+ levels and promotes cardiomyocytes proliferation/survival/regeneration.
Figure 2. The chemical structure of Chrysin. Chrysin promotes cardiac regeneration through down regulation of p38alpha and up regulation of NAD+ levels
Figure 3. Mechanistic insights into how consumption of honey, which is an integral part of the longevity-promoting blue zone diet, promotes cardiac regeneration
Figure 4. Sources of Chrysin. Chrysin, which attenuates cardiac dysfunction, can be derived from Propolis (28g/L), forest honey(5.3mg/kg), mushrooms (0.17/kg), honeydew honey (0.10mg/kg) and others.
 Thus, pharmacological formulations encompassing "Chrysin         ( 5,7-Dihydroxyflavone) or its analogues, either alone or in combination with other drugs" can be used to promote cardiomyocyte proliferation & regeneration; and protect against cardiac dysfunction.  
# Research cooperation

Undisclosed information: How does Chrysin suppress the expression of p38-α?

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References: 

CitationBoominathan, L., Mechanistic insights into how Blue zone longevity diet protects against cardiac dysfunction: Having honey on a daily basis will protect you against cardiac dysfunction and extend lifespan:Chrysin, found in propolis and honey, promotes heart regeneration and function and augments stress resistance against hypoxic stress through down regulation of p38-α, 20/February/2020, 8.10 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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