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March 10, 2020

Repurposing the anti-asthmatic drug Montelukast into an anti-tuberculosis drug: Montelukast (trade name: Singulair) deacetylates RelA/p65, inhibits inflammatory gene expression downstream of RelA/p65, inhibits TB pathogenesis, increases the efficacy of anti-TB drug, and promotes M. tuberculosis clearance via upregulation of its target gene, 10/March/2020, 8.01 am

Introduction: What they say: A study from the Singapore Immunology Network, Agency for Science, Technology and Research, Singapore; and Lee Kong Chian School of Medicine, Nanyang […]
March 10, 2020

Anti-asthmatic drug comes to the rescue of blood-stage Plasmodium infection: Pranlukast, an anti-asthmatic drug,  decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clears blood-stage malaria, via up regulation of its target gene, 10/March/2020, 7.38 am

Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that […]
March 10, 2020

Mechanistic insights into how Vitamin D3/Cholecalciferol enhances immunity against bacterial infections: Cholecalciferol-based immune enhancement therapy: Low dose Cholecalciferol/Vitamin-D3 increases SOX2 expression, and promotes innate immunity against bacterial infection, via down-regulation of its target gene, 10/March/2020, 6.18 am

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in […]