Repurposing the anti-hypertensive drug Carvedilol into an antiviral agent: Carvedilol (trade name: Coreg), increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication, via upregulation of its target gene, 10/March/2019, 12.02 am

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Introduction: What they say

A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex 15, France shows thatInterferon-Induced Spermidine-Spermine Acetyltransferase and Polyamine Depletion Restrict Zika and Chikungunya Viruses.”  This research paper was published, in the 10 August 2016 issue of the journal “Cell Host and microbe” [One of the best research journals in Infectious biology with an I.F of 12.552], by Prof. Marco Vignuzzi, Bryan C. Mounce and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that:  Repurposing the anti-hypertensive drug Carvedilol into an antiviral agent: Carvedilol (trade name: Coreg), increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication, via upregulation of its target gene, 10/March/2019, 12.01 am


What is known?

Prof. Marco Vignuzzi’s research team has recently shown that induction of type I interferon results in: a) upregulation of SAT1; b) depletion of spermidine and spermine levels; and c) inhibition of Chikungunya and Zika viruses production. They have further validated this by showing that exogenous administration of Polyamines (spermidine and spermine) restores virus replication.


From research findings to Therapeutic opportunity:

This study suggests, for the first time, that anti-hypertensive drug Carvedilol could attenuate the production of RNA viruses, such as Chikungunya virus (CHIKV) and Zika virus (ZIKV).  Carvedilol, by increasing the expression of its target gene, it may increase the expression of spermidine/spermine N1-acetyltransferase (SAT1) (Figure 1). Thereby, it may: (1) decrease polyamine spermidine and spermine levels; (2) stall CHIKV and ZIKV replication; (3) promote clearance of Zika and Chikungunya Viruses; and (4) strengthen antiviral immunity against RNA viruses. (Figure 2)

This image has an empty alt attribute; its file name is Carvedilol-inhibits-CHIKV-and-ZIKV-replication-through-induction-of-Spermidine.spermine-N1acetyltransferase-SAT-770x578.jpg

Figure 1 Mechanistic insights into how Carvedilol functions as an antiviral agent. Zingerone inhibits the replication of Chikungunya and Zika viruses through induction of SAT

This image has an empty alt attribute; its file name is Carvedilol-inhibits-CHIKV-and-ZIKV-replication-through-induction-of-Spermidine.spermine-N1acetyltransferase-SAT.jpg2_-770x578.jpg

Figure 2. Carvedilol functions as an anti-viral agent against CHIKV/ZIKV viruses.

Thus, pharmacological formulations encompassing “Carvedilol or its analogs, either alone or in combination with other drugs”, may be used to treat infections caused by chikungunya (CHIKV) and Zika (ZIKV) viruses. Given that Carvedilol is more economical and safer, without any known side-effects, compared with other antiviral drugs, it may find a larger utility in patient care as a broad-spectrum anti-viral/infective agent. 


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Carvedilol  decrease the expression of spermidine/spermine N1-acetyltransferase (SAT1)?

Amount: $ 500#

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References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L,  Repurposing the anti-hypertensive drug Carvedilol into an antiviral agent: Carvedilol (trade name: Coreg), increases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication, via upregulation of its target gene, 10/March/2019, 12.02 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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